Results 51 to 60 of about 950,411 (267)

METHODOLOGY OF ANALYSIS AND EVALUATION OF FINANCIAL CONDITION OF ENTERPRISES OF MACHINE-BUILDING INDUSTRY

open access: yesВестник университета, 2019
In this article, we consider methods for analyzing the financial state of various authors. Based on the reviewed methods, an analysis was made and an assessment of the financial condition of the machine-building industry enterprise - PJSC «Kamaz».
O. Diakonova, N. Samoiylova
doaj  

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

open access: yesMolecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan   +16 more
wiley   +1 more source

Fiscal Rules versus the Financial Condition of EU Local Government Units

open access: yesPrace Naukowe Uniwersytetu Ekonomicznego we Wrocławiu, 2023
The financial crisis and significant deterioration of public finances have led to the strength- ening of instruments aimed at ensuring the financial stability of the state, including fiscal rules.
Elżbieta Malinowska-Misiąg
doaj  

Financial condition and product market cooperation [PDF]

open access: yesJournal of Corporate Finance, 2014
We provide evidence that existing studies relating financial condition to product market cooperation produce mixed results because of unique features of the industries examined. In particular, all evidence suggesting that poor financial condition decreases cooperation comes from the airline industry during periods of high idle capacity.
Gustafson, Matthew   +2 more
openaire   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

open access: yesMolecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain   +10 more
wiley   +1 more source

IMPROVEMENT OF THE METHODS OF ROUTE SELECTION OF INNOVATIVE DEVELOPMENT OF AN ENTERPRISE ON THE BASIS OF THE ANALYSIS OF FINANCIAL AND STATISTICAL REPORTING

open access: yesСтатистика и экономика, 2016
An analysis of the indexes of the financial and innovation activity of industrial enterprises is given, six of them are identified. The methods of calculation of the indicators based on the financial and statistical reporting of enterprises is proposed ...
Irina A. Evseeva
doaj   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

open access: yesMolecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen   +14 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

open access: yesMolecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir   +13 more
wiley   +1 more source

Sovereign Indebtedness and Financial and Fiscal Conditions [PDF]

open access: yesSSRN Electronic Journal, 2019
We empirically assess the magnitudes of sovereign indebtedness responses for a sample of 123 Advanced and Emerging Market Economies, between 1980 and 2018, taking into account the changing characte...
António Afonso, João Tovar Jalles
openaire   +3 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

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