Results 71 to 80 of about 950,411 (267)

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

The Covid-19 pandemic and the financial condition of non-financial enterprises in Poland

Rozprawy Społeczne
The aim of the study was to assess the impact of the Covid-19 pandemic on the financial situation of enterprises in Poland. Material and methods The subjective scope of research included enterprises keeping accounting books that employed at least 50 ...
Agnieszka Gałecka, Małgorzata Nestoruk
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

The Impact of the Socioeconomic Potential of the Regions in Poland on Their Financial Condition as a Typology Criterion

Studia Regionalne i Lokalne
The aim of the study is to examine the relationship between the socioeconomic potential and the financial condition of regions (voivodeships) in Poland.
Janina Kotlińska, Anna Mizak, Anna Krawczyk-Sawicka   +2 more
doaj   +1 more source

FAKTOR-FAKTOR YANG MEMPENGARUHI TINGKAT KEPATUHAN PENGUSAHA KENA PAJAK BADAN PEDAGANG PENGECER PADA KANTOR WILAYAH DIREKTORAT JENDERAL PAJAK JAWA TIMUR I

Jurnal Ekonomi dan Bisnis Airlangga, 2015
Tax compliance is a force to conduct provisions or rules of taxation that are required or are required to be implemented. In a system of self-assessment, the taxpayer is given the discretion to count, deposit, and reported tax obligations.
Awit Maulinda, Mienati Somya Lesmana
doaj   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

The effect of human capital and physical capital on regional financial condition: the moderating effect of management control system. [PDF]

Heliyon, 2021
Usman A, Wirawan H, Zulkifli.
europepmc   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

External balances, trade and financial conditions [PDF]

Journal of International Economics, 2017
Abstract I present a new model for the U.S. external position that accounts for the accumulation of international debt over the past 60 years. The model is based on the present value restriction that links a country's external position to future trade flows and financial conditions in the absence of arbitrage opportunities and Ponzi schemes.
openaire   +2 more sources