Results 71 to 80 of about 5,869,068 (307)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Capital Expenditure Dynamics in ASEAN: Unveiling Determinants and The Impact of The COVID-19 Pandemic on Non-Financial Corporations

open access: yesBuletin Ekonomi Moneter dan Perbankan
This study investigates the intricate determinants influencing the capital expenditure behavior of Non-Financial Corporations (NFCs) in major ASEAN countries over the past decade.
Solikin M. Juhro   +2 more
doaj   +1 more source

Systematic approach to the analysis of receivables of the enterprise on the basis of statistical data

open access: yesEkonomìka Harčovoï Promislovostì, 2020
The article examines the economic literature on the approaches to the analysis of receivables of the enterprise. The sequence of receivables analysis has been made by stages: definition of purpose, objects, tasks of analysis, work on sources of ...
T. Stupnytska   +3 more
doaj   +1 more source

Financial Crisis Inquiry Commission

open access: yes, 2011
This website contains the research and final report for the Financial Crisis Inquiry Commission looking at the causes of the economic ...
United States. Financial Crisis Inquiry Commission.
core  

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

open access: yesMolecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu   +13 more
wiley   +1 more source

Financial Condition Index and interest rate settings: a comparative analysis [PDF]

open access: yes
In the last thirty years, there has been a widespread move towards financial liberalisation, both within and across national borders. This economic development brought researchers to investigate the link between asset prices, inflation and the conduct of
Alberto Montagnoli, Oreste Napolitano
core  

THE EFFECT OF FINANCIAL DISTRESS, FINANCIAL RATIO, AND GOOD CORPORATE GOVERNANCE ON EARNINGS MANAGEMENT [PDF]

open access: yes
The goal of earnings management, an agency-related issue, is to choose accounting rules that would enhance profits in line with the goals of the business while creating financial statements.
Arum, Enggar Diah Puspa   +2 more
core   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

open access: yesMolecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

ASSESSMENT OF THE DETERMINATS OF FINANCIAL SECURITY OF RAILWAYS IN UKRAINE

open access: yesФінансово-кредитна діяльність: проблеми теорії та практики, 2018
The paper is devoted to the study of determinants determined the level of financial security of economic systems. It is shown that the financial security of an economic system implies the achievement of a level of financial stability that will ...
I. Britchenko   +3 more
doaj   +1 more source

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