Results 61 to 70 of about 4,127,395 (385)

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

What’s the Problem, Mr. President?: Bush’s Shifting Definitions of the 2008 Financial Crisis [PDF]

, 2011
A case study is presented which examines the political rhetoric of U.S. President George W. Bush concerning the Global Financial Crisis of 2008-2009. Topics include Bush\u27s definition of the economic crisis, his reluctance to recognize the existence of
Holtzman, Richard
core   +1 more source

The Eurozone Debt Crisis and the European Banking Union:A Cautionary Tale of Failure and Reform [PDF]

, 2013
The 2008 global financial crisis spread to most of the developed economies, including those of the European Union. Unfortunately, despite decades of effort to build a Single Financial Market, almost all EU jurisdictions lacked proper crisis resolution ...
Arner, Douglas W., Avgouleas, Emilios
core   +1 more source

A stepwise emergence of evolution in the RNA world

FEBS Letters, EarlyView.
How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley   +1 more source

Financial Crisis of Metaphor [PDF]

SSRN Electronic Journal, 2009
This paper presents an analysis of the mathematical models of the prevailing orthodoxy within the field of financial economics in light of the financial crisis. The financial crisis presents a challenge to the language of orthodox financial economics.
openaire   +4 more sources

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

Current Economic and Financial Crisis – New Issues or Returning to the Old Problems? Paradigms, Causes, Effects and Solutions Adopted [PDF]

Theoretical and Applied Economics, 2011
At the ideological level, the current crisis, as the others in history, has triggered an intellectual debate among several applicable ideas: ultra-liberal theory of the "invisible hand" of Adam Smith, Keynes’s theory of state interventionism and even neo-
Felix TOTIR, Ingrid-Mihaela DRAGOTĂ
doaj   +1 more source

Theoritical Seekings in Macroeconomics

İstanbul İktisat Dergisi, 2020
Dynamics stochastics general equilibrium (DSGE) models are dominant until the 2008 global financial crisis. Although some economists have stated that macroeconomics is a mature science, others believe that macroeconomics that is based on DSGE models has ...
Emre Örün
doaj   +1 more source

Crisis Analysis and Prevention and Control of Financial Leverage Imbalance in Shareholder Equity Pledge Based on the DANP Model

Discrete Dynamics in Nature and Society, 2022
ResearchBackground. The process of economic globalization is accelerating, and the financial risks that listed companies need to face are more complicated. Research Purpose.
Fang Fang
doaj   +1 more source

Structural dynamics of the plant hormone receptor ETR1 in a native‐like membrane environment

FEBS Letters, EarlyView.
The present study unveils the structural and signaling dynamics of ETR1, a key plant ethylene receptor. Using an optimized nanodisc system and solution NMR, we captured full‐length ETR1 in a native‐like membrane environment. Our findings reveal dynamic domain uncoupling and Cu(I)‐induced rigidification, providing the first evidence of metal‐triggered ...
Moritz Lemke, Nils Alexander Lakomek, Georg Groth   +2 more
wiley   +1 more source