Results 41 to 50 of about 563,034 (303)

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Financial exclusion in Australia: can Islamic finance minimise the problem? [PDF]

open access: yes, 2016
The purpose of this study is to explore the nature and extent of financial exclusion in Australia focussing particularly the Muslim community. Financial exclusion refers to a situation where people lack access to affordable and appropriate financial ...
Rahman, Mohammad Mafizur   +2 more
core  

NON-INTEREST FINANCIAL INSTITUTIONS IN TACKLING FINANCIAL EXCLUSION AND ECONOMIC DEVELOPMENT

open access: yesThe International Journal of Humanities Technology and Civilization
This study aims to provide a solution to poverty and financial exclusion in North-East (BAY) states using non-interest financial institutions and financial technology (Fintech) to enhance economic development and accelerate the financial stability of ...
Tijjani Muhammad   +2 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

open access: yesMolecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan   +16 more
wiley   +1 more source

Role of Islamic financial institutions in addressing financial exclusion: a methodological mix approach [PDF]

open access: yes, 2023
This paper elucidates the mediating role of Islamic Financial Institutions in addressing financial exclusion in northern Nigeria, using poverty, awareness, religiosity, and attitude toward government policy as explanatory factors.
Muhammad, Tijjani   +2 more
core   +1 more source

What Factors Are Limiting Financial Inclusion and Development in Peru? Empirical Evidence

open access: yesEconomies
Despite recent efforts in Peru to boost financial inclusion, significant issues of exclusion persist, especially among vulnerable groups. This article aims to identify and analyze areas at risk of financial exclusion using a multifaceted methodology: the
Sergio Luis Náñez Alonso   +3 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

open access: yesMolecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain   +10 more
wiley   +1 more source

Passing the Buck? Examining Canadian Banks Approaches to Financial Exclusion [PDF]

open access: yes, 2012
Online resource: 37 pp.; Digital file.The purpose of this report is to examine what Canadian banks say they are doing to address financial exclusion by identifying what banks understand about its causes, consequences, and solutions.
Buckland, Jerry
core  

The Role of Islamic and Conventional Microfinance in Tackling Financial Exclusion in Bangladesh, Nigeria, and Uganda

open access: yesShirkah, 2022
There has been to pertinent study considering the growth of Islamic and conventional microfinance institutions as an antecedent of financial inclusion in Bangladesh, Nigeria, and Uganda in a single study.
Tawfik Azrak, Muzamil Edema
doaj   +1 more source

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