Results 41 to 50 of about 357,743 (260)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

THE ROLE OF STRATEGIC MANAGEMENT IN RAISING THE EFFICIENCY OF THE FINANCIAL PERFORMANCE (AN APPLIED STUDY ON ALGERIA TELECOM COMPANY) [PDF]

مجلة الاجتهاد للدراسات القانونية والاقتصادية
This paper focuses mainly on the evaluation of the Algerian Telecom Company in terms of practicing its strategic management in its scope, as well as studying various fields of strategic management that are essential and vital to raising the ...
سديري أمين, سالمي رشيد   +1 more
doaj  

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

MEASUREMENT OF FINANCIAL PERFORMANCE IN PRODUCTION SECTOR

Sakarya Üniversitesi İktisat Dergisi, 2013
Measuring effectiveness and performance of manufacturing sector, one of the basic dynamics of growth, has gained importance for companies in the evolving competence environment.
Filiz Yıldız Contuk, Hümeyra Burucu, Abdülkadir Kaya, Bener Güngör   +3 more
doaj  

Determination of financial performance measurement indicators and accounting system capabilities for financial accountability in Tehran Municipality [PDF]

مطالعات تجربی حسابداری مالی, 2017
The purpose of this study was to determine financial performance measurement indicators, assess the adequacy and capability of existing indicators, and evaluate the capabilities of the accounting system to fulfill the financial responsibility of Tehran ...
MOZHGAN MOHARRAMI, jafar babajani
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Why is the financial performance-environmental performance relationship difficult to measure

Pressacademia, 2018
Purpose- There appears to be no consensus as to the nature (positive or negative) or strength of the relationship between financial performance (FP) and environmental performance (EP). The literature seems to lean towards a positive relationship. This paper offers an explanation of the mixed empirical results. Methodology- Using publicly available data
HATTEN, Kenneth J., KEELER, James P., JAMES, William L., KİM, Kyungho   +3 more
openaire   +2 more sources

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Performance implications of strategic performance measurement in financial services firms

Accounting, Organizations and Society, 2003
This study examines the relation between measurement system satisfaction, economic performance, and two general approaches to strategic performance measurement: greater measurement diversity and improved alignment with firm strategy and value drivers.
Ittner, Christopher D, Larcker, David F, Randall, Taylor   +2 more
openaire   +3 more sources