Results 41 to 50 of about 457,574 (264)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

A study on the effect of recent financial turmoil on performance of petrochemical industries: Evidence from Tehran Stock Exchange [PDF]

Management Science Letters, 2013
This paper presents a study to investigate the effect of world’s financial turmoil on performance of petrochemical firms listed on Tehran Stock Exchange (TSE).
Babak Eslami, Mohammad Hemmati, Fatemeh Namvar   +2 more
doaj   +1 more source

The Relationship Between Share Prices and DUPONT Model Components: Evidence from Mexican Stock Market

Revista Mexicana de Economía y Finanzas Nueva Época REMEF, 2021
This article presents the possible association between the three components (profit generation, asset efficiency and financial leverage) of the DUPONT ratio and share prices. The generalized method of moments (GMM) estimation was used with a sample of 23
Luis Manuel Tovar Rocha, Julio Téllez Pérez, Gabriel Alberto Agudelo Torres   +2 more
doaj   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Measuring Local Government Financial Performance With Financial Ratios

JAS (Jurnal Akuntansi Syariah)
This research aims to analyze the financial performance of local government in the Toba Regency. The data source uses secondary data in the form of Toba Regency government financial reports for 2020-2022.
Sahala Purba, Rani Agustines Purba, Lucyanna Yosephine Simangunsong, Nadia A.V.E. Gultom, Agnes Patricia R. Sinaga   +4 more
doaj   +1 more source

MEASURING FINANCIAL PERFORMANCE: FINANCIAL RATIOS VS. ECONOMIC VALUE ADDED [PDF]

EURINT, 2020
The study presents a model of comparative analysis of financial performance based on two categories of instruments and evaluates the interdependencies between different performance measures.
Mihaela Brindușa TUDOSE, Valentina Diana RUSU, Silvia AVASILCĂI   +2 more
doaj  

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Financial Ratio Analysis For Predicting Financial Distress

Eduvest - Journal of Universal Studies, 2022
This empirical study aims to analyze the financial ratios that can predict financial distress in property and real estate companies listed on the Indonesia Stock Exchange (IDX) from 2016 to 2020. The study employs a quantitative approach with multiple linear regression analysis using eviews software.
Veronica Sonia Kinanti, Muhyarsyah Muhyarsyah   +1 more
openaire   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source