Results 71 to 80 of about 22,234,754 (301)
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
, 2018 This chapter provides a framework by drawing upon the work of Maurice Merleau-Ponty in order to conceptualize health as a mind-body-world phenomenon.
Bullington, Jennifer, +1 more
core +1 more source
Financial Literacy: An Exploratory Analysis in Portugal
Studies in Business and Economics, 2022 This work aims to verify, through an exploratory factor analysis, which are the determinants of the financial literacy of the Portuguese over 18 years old.
Tavares Fernando Oliveira +3 more
doaj +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
How do Financial Literacy, Financial Behavior, and Financial Well-Being Affect Presenteeism?
SAGE OpenPresenteeism refers to a situation in which an employee performs less optimally due to problems such as poor health, job dissatisfaction, family conflicts, and financial difficulties.
Tastaftiyan Risfandy +3 more
doaj +1 more source
2017 Well Being Trust Annual Report
, 2018 Tyler Norris, writing in the 2017 Well Being Trust Annual Report: This is a promising moment for our nation, as the importance of mental health and well-being become obvious to growing numbers of Americans and awareness of mental health disorders ...
Well Being Trust
core +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Measuring the Association between Emotional and Financial Employee Well-Being and Work Satisfaction [PDF]
Revista de Management Comparat InternationalThe article provides a concise yet significant overview of the emotional and financial well-being of employees at work, categorized as soft and hard aspects.
Nicoleta Valentina FLOREA +2 more
doaj +1 more source