Results 71 to 80 of about 793,023 (271)
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Infrastructure in South Africa: Who is to finance and who is to pay? [PDF]
Against the backdrop of shifting views on the role of government in the provision of infrastructure, this paper distinguishes between the payment for and financing of the South African Government’s infrastructure investment programme.
Estian Calitz, Johan Fourie
core
Regional railway transport funding in conditions of the Czech Republic and in the Pilsen region [PDF]
, 2010 Present situation in financing of regional railway transport does not allow sustainable development of transport services in a region and also often leads to further worsening of situation in rolling stock financing.
Benediktová, Marcela, Chlaň, Alexander
core +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
New national fiscal policy for accelerating regional development of infrastructure in Indonesia
Jurnal Tata Kelola dan Akuntabilitas Keuangan NegaraOver the past few years, regional financing in Indonesia, as regulated by law, has continued to develop. In the beginning, the regional financing schemes in Indonesia and the term used was restricted to the term regional loan, until in 2022, the ...
R. Muhammad Rouffie Putera Kesuma Runjung
doaj
Impact of implicit government guarantee on the credit spread of urban construction investment bonds
Financial InnovationFinancing sources for urban construction have garnered significant attention globally. Among various financing methods, the urban construction investment bond (UCIB) is unique to China. The UCIB credit spread, which represents the compensation for credit
Rongda Chen +5 more
doaj +1 more source
Financing housing through government-sponsored enterprises [PDF]
Three government-sponsored enterprises (GSEs)-Fannie Mae, Freddie Mac, and the Federal Home Loan Bank System-were created to improve the availability of home mortgage financing by supplementing local funding.
Larry Wall, W. Scott Frame
core
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Public Investments in Croatia [PDF]
The purpose of this paper is to analyze public investment or capital expenditures in the Republic of Croatia. The paper begins with an overview of public sector statistics regarding capital investment financing.
Anto Bajo, Katarina Ott
core
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source