Results 51 to 60 of about 55,596 (235)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

RETRACTED: Unlocking SME growth: Analyzing the government subsidies' impact on financing in China.

open access: yesPLoS ONE
Small and medium-sized enterprises (SMEs) were an important part of China's economy, but they faced challenges to growth due to financing difficulties. Government subsidies are considered as a potential way to address this problem.
Wenjing Sun   +3 more
doaj   +1 more source

Does government intervention moderate the flood risk, flood risk perceptions, and moral hazard of Malaysian household risk financing decisions?

open access: yesCogent Social Sciences
Malaysia faces increasing flood risk intensified by rapid urbanization resulting in severe damage and rising economic losses, living quarters accounted for 40% of the total damage.
Sek-Choo Tan, Zahiruddin Ghazali
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Threats and root causes of using publicly-owned lands as assets for urban infrastructure financing

open access: yesAlexandria Engineering Journal, 2018
Using publicly-owned lands as assets for urban infrastructure financing considers one of the most ambitious and encouraged approaches to finance urban infrastructure since this approach would provide the needed financing to different types of ...
Mostafa El-Nagdy   +2 more
doaj   +1 more source

A dynamic simulation model for financing strategy management of infrastructure PPP projects

open access: yesInternational Journal of Strategic Property Management, 2020
Strategic management is vital for significant infrastructure public-private partnership (PPP) projects characterised by a heavy and irreversible investment over a long period.
Yuqing Zhang, Wenhua Hou, Yan Qian
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

open access: yesFEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

The compliance of local self-government financing rules in the Republic of Serbia and the Republic of Srpska with the European Charter of Local Self-Government [PDF]

open access: yesNBP: Nauka, bezbednost, policija
A necessary precondition for the existence and functioning of local self-government is the existence of appropriate financial resources. The European Charter of Local Self-Government is an important legal act regarding the question of local self ...
Hadži-Stević Brano
doaj   +1 more source

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