Results 31 to 40 of about 37,168 (194)

Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila

open access: yesFEBS Letters, EarlyView.
Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia   +6 more
wiley   +1 more source

Regional macroeconomic outcomes under alternative arrangements for the financing of urban infrastructure [PDF]

open access: yes
Many studies, both of Australia and of comparable developed economies, have found that the economic benefits from investment in urban infrastructure are substantial. However the nature of this infrastructure is often such that it is under-provided by the
Maurreen Rimmer   +2 more
core  

Export-Import Bank: Financing of Dual-Use Exports [PDF]

open access: yes, 2013
Correspondence issued by the Government Accountability Office with an abstract that begins "Since October 1994, the Export-Import Bank of the United States (Ex-Im) has had statutory authority to facilitate the financing of U.S.
United States. Government Accountability Office.
core  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Why infrastructure financing facilities often fall short of their objectives [PDF]

open access: yes
To encourage the private funding and provision of infrastructure services, governments have used specialized financing facilities to offer financial support to investors, often in the form of grants, soft loans, or guarantees.
Klingebiel, Daniela, Ruster, Jeff
core  

Renewable Energy Project Financing: Improved Guidance and Information Sharing Needed for DOD Project-Level Officials [PDF]

open access: yes, 2012
A letter report issued by the Government Accountability Office with an abstract that begins "To finance renewable energy projects, the military services use up-front appropriations, such as operation and maintenance funds, and alternative-financing ...
United States. Government Accountability Office.
core  

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

The Size, Financing and Impact of the Public Sector Deficit, 1975-198 [PDF]

open access: yes
The manner by which the government has chosen to finance the fiscal deficit in the given period and the economic consequences of financing of government expenditures are discussed in this paper.
Manasan, Rosario G.
core  

Debt is not a dirty word: the role and use of debt in local government [PDF]

open access: yes, 2014
This research suggests the sensible use of debt by local councils can address infrastructure backlogs and positively support sustainable local communities and organisation performance.
John Comrie
core  

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

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