Results 131 to 140 of about 1,287,133 (312)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Breaking the Mortality Curve: Investment-Driven Acceleration in Life Expectancy and Insurance Innovation

open access: yesRisks
Capital investment in longevity science—research targeting the biological processes of aging through interventions like cellular reprogramming, AI-driven drug discovery, and biological age monitoring—may create significant divergence between traditional ...
David M. Dror
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

The Financing of Innovation: Learning and Stopping [PDF]

open access: yes
This paper considers the financing of a research project under uncertainty about the time of completion and the probability of eventual success.The uncertainty about future success gradually diminishes with the arrival of additional funding.The ...
Bergemann, D., Hege, U.
core   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Financing Swedish Small and Medium-Sized Enterprises: Methods, Problems and Impact [PDF]

open access: yes
Small and Medium-sized Enterprises (SMEs) are the seeds for a vital entrepreneurial economy. The Swedish SMEs, in particular, are very important for the future development of the Baltic Region.
Adli Abouzeedan
core  

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

The Financing Of Regional Development And Economic Growth In West Java Province [PDF]

open access: yes
In the context of recent decentralization of regional development in Indonesia, the local authorities and communities need to understand by how potential sources for financing regional development effect the economic growth.
Rina Indiastuti
core  

Finances publiques, finances privées

open access: yesCalenda, 2011
S’il est académique de distinguer droit public et droit privé, finances publiques et finances privées, les frontières sont aujourd’hui moins marquées du fait d’un double mouvement de « privatisation » du droit public et de « publicisation » du droit privé.
openaire   +1 more source

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