Results 41 to 50 of about 3,247 (253)

FAIR Findability / Persistenz

, 2023
Präsentation im Rahmen des Text+ FAIR February Meetup 2023: F wie Findability, 1. Februar 2023.
openaire   +2 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Enhancing Open Data Findability

Conference on Digital Government Research
Metadata is essential for improving the discoverability and findability of datasets. According to the European Data Portal (EDP), Europe’s largest open data portal, keywords and categories alone contribute to 60 percent of a dataset’s visibility. Given that datasets can have highly variable and complex contexts, we propose leveraging the power of Large
Umair Ahmed, Andrea Polini
  +4 more sources

EFSA statement on the interpretation of FAIR principles for mechanistic effect models in the regulatory environmental risk assessment of pesticides

EFSA Journal
Among its objectives, the European Food Safety Authority working group on effect models in environmental risk assessment has worked towards the development and maintenance of a framework to facilitate the assessment of effect models within the scope of ...
European Food Safety Authority (EFSA), Sandrine Charles, Andreas Focks, Jonathan T. Haselman, Edoardo Carnesecchi, Davide Gibin, Alessio Ippolito, Alberto Linguadoca, Ivana Teodorović   +8 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

An OMOP Common Data Model pipeline for electrocardiography dataset integration by standardizing signal metadata and heart rate variability features

Frontiers in Bioinformatics
Efficient data sharing is crucial for the secondary use of healthcare data, which represents one of the greatest opportunities to advance pathophysiological knowledge and improve health outcomes.
Pierluigi Reali, Valentina Tibollo, Gaia Riboni, Pierluigi Plebani, Letizia Tanca, Maria G. Signorini   +5 more
doaj   +1 more source

VIRTUAL PROJECTS: Tooling up to facilitate findability, virtual collaboration, and storytelling with data

Journal of the Medical Library Association, 2017
None
Susan Lessick
doaj   +1 more source