Results 61 to 70 of about 3,247 (253)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Transculturation of the Hero in G. Belger’s Novel “The Home of the Wanderer”
Polylinguality and Transcultural Practices, 2019 Using the methods of literary analysis, the author tries to trace the evolution of the hero of the novel by G. Belger in the aspect of the transcultural approach. The central object of the study was the “House” archetype.
Alena S Demchenko
doaj +1 more source
Wikidata as a knowledge graph for the life sciences
eLife, 2020 Wikidata is a community-maintained knowledge base that has been assembled from repositories in the fields of genomics, proteomics, genetic variants, pathways, chemical compounds, and diseases, and that adheres to the FAIR principles of findability ...
Andra Waagmeester +29 more
doaj +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Bilgi Dünyası, 2004 Information architecture is a phrase that has been around for some time, but usually in the context of information technology. However, it has recently gained credibility in the softer area of information systems design, particularly with regard to the ...
Alan Gilchrist, Tuba Tuna Günden
doaj +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
改進修正型德菲式卡片分類法探討大學圖書館網站尋獲度之研究 Using Refined Modified-Delphi Card Sorting to Analyze the Findability of University Library Websites [PDF]
Jiàoyù zīliào yǔ túshūguǎn xué, 2010 利用網站獲取資訊已經成為現代人經常從事的行為,有些網站提供了具邏輯性的架構幫助使用者方便找到資訊;但缺乏組織性的網站架構會讓使用者受挫並離開網站。值此電子化時代,網站成了遠端使用者與單位組織溝通的最佳橋樑,如何讓使用者能方便、有效率地從網站中取用所需之資訊,使網站資訊發揮應有的價值,是網站設計者必須深思的問題。本研究是以大學圖書館網站使用者為中心,提出改進修正型德菲式卡片分類法,以瞭解使用者如何組織網站中的網站標籤、以及對於各項網站標籤的命名方式,進而建立符合使用者需求之大學圖書館網站架構 ...
Jiann-Cherng Shieh, Yi-Ching Wu
doaj
Using Names Lists for Social Network Analysis
Umanistica Digitale, 2019 In this paper, I discuss using digital names lists compiled from analog sources for social network analysis. Using examples from finding aids of archival collections, I demonstrate how social network analysis can show relationships and contrasts between ...
Megan Lewis
doaj +1 more source