Results 71 to 80 of about 1,403,751 (269)

Some Issues on Reforming the Legislation on Administrative Offences

Сибирское юридическое обозрение, 2019
Some problems of modern administrative-tort law are considered. Attention is focused on a number of key problems of the current legislation on administrative offenses and on some specific proposals for its amendment.
S. I. Koryts, I. B. Bokova
doaj   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

The Monetary Penalty Clause as a Punitive Provision In Light of Coptic Documents

Journal of General Union of Arab Archaeologists
This artical aims to analyze the monetary penalty clause in Coptic documentary texts as an essential legal and punitive element that reflects the management of contractual relationships, the enforcement of laws, and the mechanisms of dispute resolution ...
Walaa Ali Abd El-Rahman
doaj   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

The degree of the coercion of the decisions based on cognition no exhaustive: specially, the fine
O grau de coerção das decisões proferidas com base em prova sumária: especialmente, a multa

Scientia Iuris, 2006
Before a society that daily clamors judicial providences so that obligations not satisfied is satisfied, it appears the need that the State-judge’s decisions are added the effective coercion means so that if equilibrate the social order.
José Manoel Arruda Alvim Netto, Teresa Arruda Alvim Wambier   +1 more
doaj  

Features of realizing the rights of consumers by the contract of the works performance (providing services).

Теорія і практика правознавства, 2017
The article is devoted to the legal analysis of the volume and content of the rights of individuals - consumers in the obligations for the performance of work and the provision of services, as well as the peculiarities of their implementation.
Віктор Петрович Янишен
doaj   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

PLATON VE DEVLET’İN EPİSTEMOLOJİSİ ÜZERİNE

Felsefe Dünyası, 2014
Nesne analizini öne çıkaran ve kimi zaman “iki dünya teorisi” olarak daadlandırılan geleneksel yoruma göre, bilgi ve inanç arasındaki fark, Platon için,nesneler hakkındaki önermeleri ya da doğruları değil, bu nesnelerin bizzat kendilerinikonu edinir ...
Fatih Öztürk
doaj  

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source