Results 91 to 100 of about 3,463,080 (339)

Mapping methods for computationally efficient and accurate structural reliability [PDF]

Mapping methods are developed to improve the accuracy and efficiency of probabilistic structural analyses with coarse finite element meshes. The mapping methods consist of the following: (1) deterministic structural analyses with fine (convergent) finite
Chamis, Christos C., Shiao, Michael C.
core   +4 more sources

Functionally-informed fine-mapping and polygenic localization of complex trait heritability

Nature Genetics, 2019
Fine-mapping aims to identify causal variants impacting complex traits. We propose PolyFun, a computationally scalable framework to improve fine-mapping accuracy by leveraging functional annotations across the entire genome—not just genome-wide ...
O. Weissbrod, F. Hormozdiari, C. Benner, R. Cui, J. Ulirsch, S. Gazal, A. Schoech, Bryce van de Geijn, Yakir A. Reshef, C. Márquez-Luna, L. O'Connor, M. Pirinen, H. Finucane, A. Price   +13 more
semanticscholar   +1 more source

Coalescent-Based Association Mapping and Fine Mapping of Complex Trait Loci [PDF]

Genetics, 2005
Abstract We outline a general coalescent framework for using genotype data in linkage disequilibrium-based mapping studies. Our approach unifies two main goals of gene mapping that have generally been treated separately in the past: detecting association (i.e., significance testing) and estimating the location of the causative ...
Sebastian, Zöllner, Jonathan K, Pritchard   +1 more
openaire   +2 more sources

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Genome-Wide Association and Mendelian Randomization Analysis Reveal the Causal Relationship Between White Blood Cell Subtypes and Asthma in Africans

Frontiers in Genetics, 2021
Background: White blood cell (WBC) traits and their subtypes such as basophil count (Bas), eosinophil count (Eos), lymphocyte count (Lym), monocyte count (Mon), and neutrophil counts (Neu) are known to be associated with diseases such as stroke ...
Opeyemi Soremekun, Chisom Soremekun, Chisom Soremekun, Tafadzwa Machipisa, Tafadzwa Machipisa, Mahmoud Soliman, Oyekanmi Nashiru, Tinashe Chikowore, Tinashe Chikowore, Segun Fatumo, Segun Fatumo, Segun Fatumo   +11 more
doaj   +1 more source

Fighting Fire with Fire: Technology in Child Sex Trafficking [PDF]

, 2014
We map real articulation data for five Swedish phonemen sequences onto parameters of a biomechanical tongue model that produces movement and muscle activations from position data. The movement produced is broadly correct and could likely be improved by a
Leary, Mary Graw
core   +1 more source

Development of Thick-foil and Fine-pitch GEMs with a Laser Etching Technique

, 2009
We have produced thick-foil and fine-pitch gas electron multipliers (GEMs) using a laser etching technique. To improve production yield we have employed a new material, Liquid Crystal Polymer, instead of polyimide as an insulator layer.
A. Harayama, A. Hayato, Altunbas, Balau, Bellazzini, Benlloch, Black, Breskin, Costa, F. Asami, H. Hamagaki, H. Tawara, Hill, K. Abe, K. Makishima, Kobayashi, Meinschad, S. Iwamoto, S. Konami, S. Nakamura, Sauli, Sauli, Simon, T. Iwahashi, T. Tamagawa, Tamagawa, Tamagawa, Tawara, Y.L. Yamaguchi, Yasuda   +29 more
core   +1 more source

Multiple QTL for horticultural traits and quantitative resistance to Phytophthora infestans linked on Solanum habrochaites chromosome 11. [PDF]

, 2014
Previously, a Phytophthora infestans resistance QTL from Solanum habrochaites chromosome 11 was introgressed into cultivated tomato (S. lycopersicum). Fine mapping of this resistance QTL using near-isogenic lines (NILs) revealed some co-located QTL with ...
Haggard, J Erron, Johnson, Emily B, St Clair, Dina A   +2 more
core   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Genetic Analysis and Fine Mapping of QTL for the Erect Leaf in Mutant mths29 Induced through Fast Neutron in Wheat

Biology
The erect leaf plays a crucial role in determining plant architecture, with its growth and development regulated by genetic factors. However, there has been a lack of comprehensive studies on the regulatory mechanisms governing wheat lamina joint ...
Zhixin Yang, Jiayu Gu, Minghui Zhao, Xiaofeng Fan, Huijun Guo, Yongdun Xie, Jinfeng Zhang, Hongchun Xiong, Linshu Zhao, Shirong Zhao, Yuping Ding, Fuquan Kong, Li Sui, Le Xu, Luxiang Liu   +14 more
doaj   +1 more source