Results 111 to 120 of about 3,463,080 (339)

SlGID1a Is a Putative Candidate Gene for qtph1.1, a Major-Effect Quantitative Trait Locus Controlling Tomato Plant Height

Frontiers in Genetics, 2020
Plant height is an important agronomic trait in crops. Several genes underlying tomato (Solanum lycopersicum) plant height mutants have been cloned. However, few quantitative trait genes for plant height have been identified in tomato.
Xiaolin Liu, Xiaolin Liu, Wencai Yang, Jing Wang, Mengxia Yang, Kai Wei, Xiaoyan Liu, Zhengkun Qiu, Tong van Giang, Xiaoxuan Wang, Yanmei Guo, Junming Li, Lei Liu, Jinshuai Shu, Yongchen Du, Zejun Huang   +15 more
doaj   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Fine-mapping, trans-ancestral, and genomic analyses identify causal variants, cells, genes, and drug targets for type 1 diabetes

Nature Genetics, 2020
We report the largest and most diverse genetic study of type 1 diabetes (T1D) to date (61,427 participants), yielding 78 genome-wide-significant (P 
Catherine C. Robertson, J. Inshaw, Suna Onengut-Gumuscu, Wei-Min Chen, David Flores Santa Cruz, Hanzhi Yang, A. Cutler, Daniel J. M. Crouch, Emily Farber, S. L. Bridges, J. Edberg, R. Kimberly, J. Buckner, P. Deloukas, J. Divers, D. Dabelea, J. Lawrence, S. Marcovina, Amy S. Shah, C. Greenbaum, Mark A. Atkinson, P. Gregersen, J. Oksenberg, F. Pociot, M. Rewers, A. Steck, D. Dunger, Patrick Flemming Stephen S. John A. Concannon Pociot Rich Todd, P. Concannon, S. Rich, John A Todd, L. Wicker, John A Todd   +32 more
semanticscholar   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

CRISPR-Cas9 enrichment and long read sequencing for fine mapping in plants

Plant Methods, 2020
Background Genomic methods for identifying causative variants for trait loci applicable to a wide range of germplasm are required for plant biologists and breeders to understand the genetic control of trait variation. Results We implemented Cas9-targeted
E. López-Girona, M. Davy, N. Albert, E. Hilario, Maia E. M. Smart, C. Kirk, Susan J Thomson, D. Chagné   +7 more
semanticscholar   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Genetic Analysis and Mapping of an Enclosed Panicle Mutant Locus esp1 in Rice (Oryza sativa L.)

Journal of Integrative Agriculture, 2012
A mutant was isolated from the M2 of 60Co-γ ray mutagenized male-fertility restorer line Zao-R974 in rice. The mutant showed pleiotropic phenotypes including dwarfism, delayed heading time, short and partially enclosed panicles, short uppermost internode,
Yuan-lin DUAN, Hua-zhong GUAN, Ming ZHUO, Zhi-wei CHEN, Wen-tao LI, Run-sen PAN, Da-mei MAO, Yuan-chang ZHOU, Wei-ren WU   +8 more
doaj   +1 more source

Naturalness of Neutralino Dark Matter

, 2013
We investigate the level of fine-tuning of neutralino Dark Matter below 200 GeV in the low-energy phenomenological minimal supersymmetric Standard Model taking into account the newest results from XENON100 and the Large Hadron Collider as well as all ...
Grothaus, Philipp, Lindner, Manfred, Takanishi, Yasutaka   +2 more
core   +1 more source

Fine-scale mapping of meiotic recombination in Asians [PDF]

BMC Genetics, 2013
Abstract Background Meiotic recombination causes a shuffling of homologous chromosomes as they are passed from parents to children. Finding the genomic locations where these crossovers occur is important for genetic association studies, understanding population genetic variation, and predicting disease-causing ...
Bleazard, Thomas, Ju, Young Seok, Sung, Joohon, Seo, Jeong-Sun   +3 more
openaire   +2 more sources