Results 121 to 130 of about 3,463,080 (339)
Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker +16 more
wiley +1 more source
Frontiers in Plant Science, 2020 Wheat leaf rust, caused by the fungus Puccinia triticina Eriks. (Pt), is a destructive disease found throughout common wheat production areas worldwide.
Lina Qiu +13 more
doaj +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
The impact of short tandem repeat variation on gene expression. [PDF]
, 2019 Short tandem repeats (STRs) have been implicated in a variety of complex traits in humans. However, genome-wide studies of the effects of STRs on gene expression thus far have had limited power to detect associations and provide insights into putative ...
Fotsing, Stephanie Feupe +7 more
core +1 more source
Spitzer spectral line mapping of protostellar outflows: I. Basic data and outflow energetics
, 2009 We report the results of spectroscopic mapping observations carried out toward protostellar outflows in the BHR71, L1157, L1448, NGC 2071, and VLA 1623 molecular regions using the Infrared Spectrograph (IRS) of the Spitzer Space Telescope.
Allen +50 more
core +3 more sources
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Fine mapping of a novel wax crystal-sparse leaf3 gene in rice
Journal of Integrative Agriculture, 2017 Cuticular wax plays an important role in protecting plants against water loss and pathogen infection and in the adaptations to environmental stresses. The genetic mechanism of the biosynthesis and accumulation of epicuticular wax in rice remains largely ...
Hong-bing GONG +12 more
doaj +1 more source
‘Pre-plan mapping’, networks, capital resources and community strategies in England [PDF]
, 2002 In this working paper we discuss current attempts to engage communities in planning policy formulation in the UK. In particular we focus on the preparation of Community Strategies (CS) in England to inform local public policy and the wider proposals ...
Doak, Joe, Parker, Gavin
core +1 more source
, 2019 This paper presents a novel spline-based meshing technique that allows for usage of boundary-conforming meshes for unsteady flow and temperature simulations in co-rotating twin-screw extruders.
Elgeti, Stefanie +3 more
core +1 more source
Genome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuria
Nature Communications, 2019 Increased levels of the urinary albumin-to-creatinine ratio (UACR) are associated with higher risk of kidney disease progression and cardiovascular events, but underlying mechanisms are incompletely understood. Here, we conduct trans-ethnic (n = 564,257)
A. Teumer +185 more
semanticscholar +1 more source