Results 131 to 140 of about 3,463,080 (339)
Finely quasiconformal mappings
Proceedings of the Royal Society of Edinburgh: Section A MathematicsWe introduce a relaxed version of the metric definition of quasiconformality that is natural also for mappings of low regularity, including $W_{\mathrm{loc}}^{1,1}({\mathbb R}^n;{\mathbb R}^n)$ -mappings. Then we show on the plane that this relaxed definition can be used to prove Sobolev regularity, and that these ‘finely ...
openaire +2 more sources
Fine Mapping of the NRG1 Hirschsprung's Disease Locus
PLoS ONE, 2011 The primary pathology of Hirschsprung's disease (HSCR, colon aganglionosis) is the absence of ganglia in variable lengths of the hindgut, resulting in functional obstruction. HSCR is attributed to a failure of migration of the enteric ganglion precursors along the developing gut.
Chung, HY +18 more
openaire +6 more sources
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Journal of Integrative Agriculture, 2014 Soybean mosaic virus (SMV) disease is one of the most destructive viral diseases in soybean (Glycine max (L.) Merr.). SMV strain SC3 is the major prevalent strain in Huang-Huai and Yangtze valleys, China.
Gui-jie ZHENG +8 more
doaj +1 more source
echolocatoR: an automated end-to-end statistical and functional genomic fine-mapping pipeline
bioRxiv, 2020 Summary echolocatoR integrates a diverse suite of statistical and functional fine-mapping tools in order to identify, test enrichment in, and visualize high-confidence causal consensus variants in any phenotype.
B. Schilder, J. Humphrey, T. Raj
semanticscholar +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Characterization of a Thermo-Inducible Chlorophyll-Deficient Mutant in Barley
Frontiers in Plant Science, 2017 Leaf color is an important trait for not only controlling crop yield but also monitoring plant status under temperature stress. In this study, a thermo-inducible chlorophyll-deficient mutant, named V-V-Y, was identified from a gamma-radiated population ...
Rong Wang +16 more
doaj +1 more source
Fine-mapping inflammatory bowel disease loci to single variant resolution
Nature, 2017 Inflammatory bowel diseases are chronic gastrointestinal inflammatory disorders that affect millions of people worldwide. Genome-wide association studies have identified 200 inflammatory bowel disease-associated loci, but few have been conclusively ...
Hailiang Huang +45 more
semanticscholar +1 more source
Fine-mapping of Parkinson’s disease susceptibility loci identifies putative causal variants
bioRxiv, 2020 Recent genome-wide association studies have identified 78 loci associated with Parkinson’s Disease susceptibility but the underlying mechanisms remain largely unclear.
B. Schilder, T. Raj
semanticscholar +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source