Results 11 to 20 of about 3,463,080 (339)

Fine-mapping genetic associations. [PDF]

Human Molecular Genetics, 2020
While thousands of genetic variants have been associated with human traits, identifying the subset of those variants that are causal requires a further 'fine-mapping' step.
A. Hutchinson, J. Asimit, C. Wallace
semanticscholar   +3 more sources

Integrating local fine food traceability mapping in Vietnam’s fine dining sector

Applied Food Research
Purpose: Ensuring food traceability in the dining sector has become an urgent priority due to rising consumer demand for authenticity, sustainability, and transparency in food sourcing. However, fragmented traceability regulations and limited adoption of
Minh Thanh Le, Phuong-Anh Thi Dang, Cong Yen Le, Thanh Thao Thi Nguyen   +3 more
doaj   +2 more sources

Improving fine-mapping by modeling infinitesimal effects

Nature Genetics, 2023
AbstractFine-mapping aims to identify causal variants for phenotypes. Bayesian fine-mapping algorithms (e.g.: SuSiE, FINEMAP, ABF, and COJO-ABF) are widely used, but assessing posterior probability calibration remains challenging in real data, where model misspecification likely exists, and true causal variants are unknown.
R. Cui, Roy A Elzur, M. Kanai, J. Ulirsch, O. Weissbrod, M. Daly, B. Neale, Z. Fan, H. Finucane   +8 more
semanticscholar   +3 more sources

Association mapping and fine mapping with TreeLD [PDF]

Bioinformatics, 2005
The program package TreeLD implements a unified approach to association mapping and fine mapping of complex trait loci and a novel approach to visualizing association data, based on an inferred ancestry of the sample. Fundamentally, the TreeLD approach is based on the idea that the evidence for association at a particular position is contained in the ...
Sebastian, Zöllner, Xiaoquan, Wen, Jonathan K, Pritchard   +2 more
openaire   +2 more sources

Fine-mapping studies distinguish genetic risks for childhood- and adult-onset asthma in the HLA region

Genome Medicine, 2022
Background Genome-wide association studies of asthma have revealed robust associations with variation across the human leukocyte antigen (HLA) complex with independent associations in the HLA class I and class II regions for both childhood-onset asthma ...
Selene M. Clay, Nathan Schoettler, Andrew M. Goldstein, Peter Carbonetto, Matthew Dapas, Matthew C. Altman, Mario G. Rosasco, James E. Gern, Daniel J. Jackson, Hae Kyung Im, Matthew Stephens, Dan L. Nicolae, Carole Ober   +12 more
doaj   +1 more source

Multi-ancestry fine mapping implicates OAS1 splicing in risk of severe COVID-19

Nature Genetics, 2022
The OAS1/2/3 cluster has been identified as a risk locus for severe COVID-19 among individuals of European ancestry, with a protective haplotype of approximately 75 kilobases (kb) derived from Neanderthals in the chromosomal region 12q24.13.
J. Huffman, G. Butler-Laporte, Atlas Khan, E. Pairo-Castineira, Theodore G. Drivas, G. Peloso, T. Nakanishi, A. Ganna, A. Verma, J. Baillie, K. Kiryluk, J. B. Richards, H. Zeberg   +12 more
semanticscholar   +1 more source

A Morphology Filter-Assisted Extreme-Point Symmetric Mode Decomposition (MF-ESMD) Denoising Method for Bridge Dynamic Deflection Based on Ground-Based Microwave Interferometry

Shock and Vibration, 2020
Bridge dynamic deflection is an important indicator of structure safety detection. Ground-based microwave interferometry is widely used in bridge dynamic deflection monitoring because it has the advantages of noncontact measurement and high precision ...
Xianglei Liu, Mengzhuo Jiang, Ziqi Liu, Hui Wang   +3 more
doaj   +1 more source

A high-resolution HLA reference panel capturing global population diversity enables multi-ancestry fine-mapping in HIV host response

Nature Genetics, 2021
Fine-mapping to plausible causal variation may be more effective in multi-ancestry cohorts, particularly in the MHC, which has population-specific structure.
Yang Luo, M. Kanai, Wanson Choi, Xinyi Li, S. Sakaue, Kenichi Yamamoto, K. Ogawa, M. Gutierrez-Arcelus, P. Gregersen, P. Stuart, James T. Elder, L. Forer, S. Schönherr, C. Fuchsberger, A. Smith, J. Fellay, M. Carrington, D. Haas, Xiuqing Guo, Nicholette D. Palmer, Y. Chen, J. Rotter, K. Taylor, S. Rich, A. Correa, James G. Wilson, S. Kathiresan, M. Cho, A. Metspalu, T. Esko, Y. Okada, B. Han, P. McLaren, S. Raychaudhuri   +33 more
semanticscholar   +1 more source

Fine mapping – 19th century style [PDF]

BMC Genetics, 2005
Abstract Background There is great interest in the use of computationally intensive methods for fine mapping of marker data. In this paper we develop methods based upon ideas originally proposed 100 years ago in the context of spatial clustering.
Molitor, John, Zhao, Keyan, Marjoram, Paul   +2 more
openaire   +2 more sources

Insights from complex trait fine-mapping across diverse populations

medRxiv, 2021
Despite the great success of genome-wide association studies (GWAS) in identifying genetic loci significantly associated with diseases, the vast majority of causal variants underlying disease-associated loci have not been identified.
M. Kanai, J. Ulirsch, J. Karjalainen, M. Kurki, K. Karczewski, E. Fauman, Qingbo S. Wang, Hannah N. Jacobs, F. Aguet, K. Ardlie, N. Kerimov, Kaur Alasoo, C. Benner, K. Ishigaki, S. Sakaue, Steven K. Reilly, Y. Kamatani, K. Matsuda, A. Palotie, B. Neale, R. Tewhey, Pardis C Sabeti, Y. Okada, M. Daly, H. Finucane   +24 more
semanticscholar   +1 more source