Results 31 to 40 of about 3,463,080 (339)

Strategies for fine-mapping complex traits [PDF]

Human Molecular Genetics, 2015
Genome-wide association studies (GWAS) have identified thousands of robust and replicable genetic associations for complex disease. However, the identification of the causal variants that underlie these associations has been more difficult. This problem of fine-mapping association signals predates GWAS, but the last few years have seen a surge of ...
Spain, Sarah L., Barrett, Jeffrey C.
openaire   +2 more sources

Technical Note: The impact of spatial scale in bias correction of climate model output for hydrologic impact studies [PDF]

, 2016
Statistical downscaling is a commonly used technique for translating large-scale climate model output to a scale appropriate for assessing impacts. To ensure downscaled meteorology can be used in climate impact studies, downscaling must correct biases in
Ficklin, Darren L., Maurer, Edwin P., Wang, W.   +2 more
core   +3 more sources

Multi-ancestry meta-analysis and fine-mapping in Alzheimer’s disease

Molecular Psychiatry, 2022
Genome-wide association studies (GWAS) of Alzheimer’s disease are predominantly carried out in European ancestry individuals despite the known variation in genetic architecture and disease prevalence across global populations. We leveraged published GWAS
J. Lake, Caroline Warly Solsberg, J. Kim, Juliana Acosta-Uribe, Mary B Makarious, Zizheng Li, K. Levine, P. Heutink, Chelsea X. Alvarado, Dan Vitale, Sarang Kang, Jungsoo Gim, K. Lee, S. Piña-Escudero, L. Ferrucci, A. Singleton, C. Blauwendraat, M. Nalls, Jennifer S. Yokoyama, H. Leonard   +19 more
semanticscholar   +1 more source

Fine Mapping of fw6.3, a Major-Effect Quantitative Trait Locus That Controls Fruit Weight in Tomato

Plants, 2023
Tomato (Solanum lycopersicum) is a widely consumed vegetable, and the tomato fruit weight is a key yield component. Many quantitative trait loci (QTLs) controlling tomato fruit weight have been identified, and six of them have been fine-mapped and cloned.
Yu Ning, Kai Wei, Shanshan Li, Li Zhang, Ziyue Chen, Feifei Lu, Pei Yang, Mengxia Yang, Xiaolin Liu, Xiaoyan Liu, Xiaotian Wang, Xue Cao, Xiaoxuan Wang, Yanmei Guo, Lei Liu, Xin Li, Yongchen Du, Junming Li, Zejun Huang   +18 more
doaj   +1 more source

A deep learning method for HLA imputation and trans-ethnic MHC fine-mapping of type 1 diabetes

Nature Communications, 2021
Conventional human leukocyte antigen (HLA) imputation methods drop their performance for infrequent alleles, which is one of the factors that reduce the reliability of trans-ethnic major histocompatibility complex (MHC) fine-mapping due to inter-ethnic ...
Tatsuhiko Naito, Ken Suzuki, Jun Hirata, Y. Kamatani, K. Matsuda, Tatsushi Toda, Y. Okada   +6 more
semanticscholar   +1 more source

Construction of a High-Density Genetic Map Based on SLAF Markers and QTL Analysis of Leaf Size in Rice

Frontiers in Plant Science, 2020
Leaf shape is an important agronomic trait for constructing an ideal plant type in rice, and high-density genetic map is facilitative in improving accuracy and efficiency for quantitative trait loci (QTL) analysis of leaf trait.
Yi Wen, Yi Wen, Yunxia Fang, Peng Hu, Yiqing Tan, Yueying Wang, Linlin Hou, Xuemei Deng, Hao Wu, Lixin Zhu, Li Zhu, Guang Chen, Dali Zeng, Longbiao Guo, Guangheng Zhang, Zhenyu Gao, Guojun Dong, Deyong Ren, Lan Shen, Qiang Zhang, Dawei Xue, Qian Qian, Qian Qian, Jiang Hu   +23 more
doaj   +1 more source

A catalog of GWAS fine-mapping efforts in autoimmune disease

American Journal of Human Genetics, 2021
Summary Genome-wide association studies (GWASs) have enabled unbiased identification of genetic loci contributing to common complex diseases. Because GWAS loci often harbor many variants and genes, it remains a major challenge to move from GWASs ...
Minal Çalışkan, Christopher D. Brown, J. Maranville   +2 more
semanticscholar   +1 more source

Allele-Specific QTL Fine-Mapping with PLASMA [PDF]

The American Journal of Human Genetics, 2019
AbstractAlthough quantitative trait locus (QTL) associations have been identified for many molecular traits such as gene expression, it remains challenging to distinguish the causal nucleotide from nearby variants. In addition to traditional QTLs by association, allele-specific (AS) QTLs are a powerful measure of cis-regulation that are largely ...
Wang, Austin T., Shetty, Anamay, O’Connor, Edward, Bell, Connor, Pomerantz, Mark M., Freedman, Matthew L., Gusev, Alexander   +6 more
openaire   +2 more sources

ANNORE: genetic fine-mapping with functional annotation

Human Molecular Genetics, 2021
Abstract Genome-wide association studies (GWASs) have successfully identified loci of the human genome implicated in numerous complex traits. However, the limitations of this study design make it difficult to identify specific causal variants or biological mechanisms of association.
Virginia Fisher, Paola Sebastiani, L Adrienne Cupples, Ching-Ti Liu   +3 more
openaire   +2 more sources

Fine Mapping of the Leaf Rust Resistance Gene Lr65 in Spelt Wheat ‘Altgold’

Frontiers in Plant Science, 2021
Wheat leaf rust (also known as brown rust), caused by the fungal pathogen Puccinia triticina Erikss. (Pt), is one by far the most troublesome wheat disease worldwide. The exploitation of resistance genes has long been considered as the most effective and
Qiang Zhang, Wenxin Wei, Xiangxi Zuansun, Shengnan Zhang, Chen Wang, Nannan Liu, Lina Qiu, Weidong Wang, Weilong Guo, Jun Ma, Huiru Peng, Zhaorong Hu, Qixin Sun, Chaojie Xie   +13 more
doaj   +1 more source