Results 51 to 60 of about 3,463,080 (339)

A simple new approach to variable selection in regression, with application to genetic fine-mapping

bioRxiv, 2018
We introduce a simple new approach to variable selection in linear regression, and to quantifying uncertainty in selected variables. The approach is based on a new model – the “Sum of Single Effects” (SuSiE) model – which comes from writing the sparse ...
Gao Wang, Abhishek K. Sarkar, P. Carbonetto, M. Stephens   +3 more
semanticscholar   +1 more source

Single-Cell Epigenomics and Functional Fine-Mapping of Atherosclerosis GWAS Loci

Circulation Research, 2021
Supplemental Digital Content is available in the text. Rationale: Genome-wide association studies have identified hundreds of loci associated with coronary artery disease (CAD).
T. Örd, K. Õunap, L. Stolze, R. Aherrahrou, V. Nurminen, A. Toropainen, Ilakya Selvarajan, T. Lönnberg, E. Aavik, S. Ylä-Herttuala, M. Civelek, C. Romanoski, M. Kaikkonen   +12 more
semanticscholar   +1 more source

Whole-exome imputation within UK Biobank powers rare coding variant association and fine-mapping analyses

medRxiv, 2020
Exome association studies to date have generally been underpowered to systematically evaluate the phenotypic impact of very rare coding variants. We leveraged extensive haplotype sharing between 49,960 exome-sequenced UK Biobank participants and the ...
Alison R. Barton, Maxwell A. Sherman, R. E. Mukamel, Po-Ru Loh   +3 more
semanticscholar   +1 more source

Discovery of the Genomic Region and Candidate Genes of the Scarlet Red Flesh Color (Yscr) Locus in Watermelon (Citrullus Lanatus L.)

Frontiers in Plant Science, 2020
The flesh color of watermelon (Citrullus lanatus) is an important fruit quality trait that helps to determine fruit attractiveness and is potentially beneficial to human health.
Na Li, Jianli Shang, Jiming Wang, Dan Zhou, Nannan Li, Shuangwu Ma   +5 more
doaj   +1 more source

Fine Mapping of Clubroot Resistance Loci CRA8.1 and Candidate Gene Analysis in Chinese Cabbage (Brassica rapa L.)

Frontiers in Plant Science, 2022
Clubroot is caused by Plasmodiophora brassicae, which threatens Brassicaceae crop production worldwide. In recent years, there has been an outbreak and rapid spread of clubroot in many major cruciferous crop-producing areas of China.
Yanyan Wang, Xianyu Xiang, Fan Huang, Wenlin Yu, Xueqing Zhou, Baojun Li, Baojun Li, Yunyun Zhang, Yunyun Zhang, Peng Chen, Chunyu Zhang   +10 more
doaj   +1 more source

Fine Mapping of Cla015407 Controlling Plant Height in Watermelon

Journal of the American Society for Horticultural Science, 2021
The plant compact and dwarf growth habit is an important agronomic trait when breeding watermelon (Citrullus lanatus) cultivars because of their reduced vine length, high-density planting, and better land utilization; however, the genetic basis of the ...
Taifeng Zhang, Jiajun Liu, S. Amanullah, Zhuo Ding, Haonan Cui, F. Luan, P. Gao   +6 more
semanticscholar   +1 more source

Fine mapping of eight psoriasis susceptibility loci [PDF]

European Journal of Human Genetics, 2014
Previous studies have identified 41 independent genome-wide significant psoriasis susceptibility loci. After our first psoriasis genome-wide association study, we designed a custom genotyping array to fine-map eight genome-wide significant susceptibility loci known at that time (IL23R, IL13, IL12B, TNIP1, MHC, TNFAIP3, IL23A and RNF114) enabling ...
Das, Sayantan, Stuart, Philip E, Ding, Jun, Tejasvi, Trilokraj, Li, Yanming, Tsoi, Lam C., Chandran, Vinod, Fischer, Judith, Helms, Cynthia, Duffin, Kristina Callis, Voorhees, John J, Bowcock, Anne M., Krueger, Gerald G, Lathrop, Mark, Nair, Rajan P, Rahman, Proton, Abecasis, Goncalo R., Gladman, Dafna, Elder, James T.   +18 more
openaire   +3 more sources

On the stability of the Discrete Generalized Multigroup method [PDF]

, 2013
This paper investigates the stability of the recondensation procedure of the Discrete Generalized Multigroup method and proposes alternatives to improve stability of the original formulation.
Forget, Benoit, Forget, Benoit Robert Yves, Gibson, Nathan A., Gibson, Nathan Andrew   +3 more
core   +1 more source

Evidence of the Role of QTL Epistatic Interactions in the Increase of Melon Fruit Flesh Content during Domestication

Agronomy, 2020
Cultivated melon was domesticated from wild melons, which produce small fruits with non-edible fruit flesh. The increase in fruit flesh is one of the major domestication achievements in this species.
Chaymaa Riahi, Juan Luis Reig-Valiente, Belén Picó, Aurora Díaz, Maria José Gonzalo, Antonio José Monforte   +5 more
doaj   +1 more source

Multi-Objective Synthesis of Filtering Dipole Array Based on Tuning-Space Mapping [PDF]

, 2015
In the paper, we apply tuning-space mapping to multi-objective synthesis of a filtering antenna. The antenna is going to be implemented as a planar dipole array with serial feeding.
Lacik, J., Raida, Zbyněk, Vsetula, P.
core   +2 more sources