Results 51 to 60 of about 4,152,355 (273)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Weight status and gender-related differences in motor skills and in child care : based physical activity in young children [PDF]

, 2012
: BACKGROUND: Over the last decades, a decline in motor skills and in physical activity and an increase in obesity has been observed in children. However, there is a lack of data in young children. We tested if differences in motor skills and in physical
Kakebeeke, T. H., Kakebeeke, T.H., Puder Jardena J, Jérôme Barral, Barral Jérôme, Kriemler Susi, Kriemler, S., Tanja H Kakebeeke, Kakebeeke Tanja H, Longchamp, A., Bonvin, A., Jardena J Puder, Puder, J.J., Barral, J., Puder, J. J., Marques-Vidal Pedro, Susi Kriemler, Anouk Longchamp, Marques-Vidal, P., Bonvin Antoine, Antoine Bonvin, Longchamp Anouk, Pedro Marques-Vidal   +22 more
core   +2 more sources

Analysis of Gross Motor and Fine Motoric on Learning Outcomes of Physical Education at Public Elementary Schools

Active: journal of physical education, sport, health and recreation, 2020
This research was conducted to analyze gross motor skills and fine motor skills with the learning outcomes of PJOK (Physical Education Sports Health) in Public Elementary School 1 Sumbergedong students. This type of research is a quantitative descriptive
Henri Gunawan Pratama, Efi Ika Febriandari, Danang Ari Santoso   +2 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Adding up fine motor skills: Developmental relations between manual dexterity and numerical abilities

Acta Psychologica, 2023
The strength and development of the relationship between mathematical and motor skills is explored across three age groups of normally developing children. The presence of this relationship is postulated in classical accounts of human development.
Venera Gashaj, Dragan Trninic
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Gross, Fine and Visual-Motor Skills in Children with Language Disorder, Speech Sound Disorder and Their Combination

Brain Sciences, 2022
Increasing evidence shows that children with Communication Disorders (CDs) may show gross, fine, and visual-motor difficulties compared to children with typical development. Accordingly, the present study aims to characterize gross, fine and visual-motor
Cristiana Varuzza, Barbara D’Aiello, Giulia Lazzaro, Fabio Quarin, Paola De Rose, Paola Bergonzini, Deny Menghini, Andrea Marini, Stefano Vicari   +8 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Fine motor skills in a population of children in remote Australia with high levels of prenatal alcohol exposure and Fetal Alcohol Spectrum Disorder

BMC Pediatrics, 2017
Background Many children in the remote Fitzroy Valley region of Western Australia have prenatal alcohol exposure (PAE). Individuals with PAE can have neurodevelopmental impairments and be diagnosed with one of several types of Fetal Alcohol Spectrum ...
Robyn Doney, Barbara R. Lucas, Rochelle E. Watkins, Tracey W. Tsang, Kay Sauer, Peter Howat, Jane Latimer, James P. Fitzpatrick, June Oscar, Maureen Carter, Elizabeth J. Elliott   +10 more
doaj   +1 more source