Results 81 to 90 of about 45,276 (287)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

DEVELOPMENT OF FINE MOTOR SKILLS IN CHILDREN

open access: yes, 2022
Fine motor skills are important in the development of such motor activity of a child as mental activity, cognitive processes-memory, thinking, imagination, etc. It is very important to develop fine motor skills in early childhood, more precisely up to three years. In the first six months after birth, the brain reaches 50 percent of its adult potential,
openaire   +3 more sources

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

open access: yesFEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui   +10 more
wiley   +1 more source

Motor coordination among Greek children: from assessment to intervention [PDF]

open access: yes, 2010
A Thesis submitted in partial fulfilment of the requirements of the University of Wolverhampton for the degree of Doctor of PhilosophyBackground: Developmental Coordination Disorder (DCD) describes children with a difficulty to acquire age-specific motor
Tsiotra, Georgia D.
core  

FINE MOTOR SKILLS IN PRESCHOOL CHILDREN

open access: yes, 2021
Fina motorika predstavlja dio motoričkog razvoja kroz koje dijete prolazi. Dijete od pete godine počinje intenzivnije raditi na finoj motorici te intenzivniji razvoj traje do desete godine njegova života.
Šutalo, Mislav
core  

The skills required for transition to university and study in biological sciences: A student perspective

open access: yesFEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

The Impact of Birth Season and Sex on Motor Skills in 2-Year-Old Children: A Study in Jinhua, Eastern China

open access: yesLife
Background: This study investigates the effects of birth season and sex on the development of gross and fine motor skills in 2-year-old children in Jinhua, Eastern China.
Yuanye Zhu   +7 more
doaj   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

open access: yesFEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji   +2 more
wiley   +1 more source

Effect of hyperbaric environment on fine motor skills [PDF]

open access: yes, 2017
Title: Effect of hyperbaric environment on fine motor skills Objectives: The aim of study is to assess the changes fine motor skills due to hyperbaric environment in preparation for selected tests of fine motor skills.
Les, Martin
core  

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

open access: yesFEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer   +7 more
wiley   +1 more source

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