Results 31 to 40 of about 1,401 (209)

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

Studies on the Effect of Moisture Content and Coarse and Fine Particle Concentration on Segregation in Bins

KONA Powder and Particle Journal, 1996
Previous work by the author1-4) on particle size segregation in bins has been extended to consider the effect of the concentration of coarse particles. At low coarse concentrations a simplification can be achieved by plotting the non-dimensional concentration of coarse material C/CF to summarise the profile.
openaire   +3 more sources

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Combustion characteristics of different types of quasi-particles in iron ore sintering process

工程科学学报, 2019
The iron ore sintering process is the main source of NOx emissions and accounts for about 48% of the total NOx emissions in the iron and steel industry.
MA Peng-nan, CHENG Ming, ZHOU Ming-xi, LI Ya-wei, ZHOU Hao   +4 more
doaj   +1 more source

Experimental and DEM Study on the Mechanical Behaviors of Sand–Fines Mixtures with Different Fines Contents and Particle Size Ratios

Materials
To clarify the regulatory laws of the fines content (FC) and particle size ratio (SR) on the mechanical properties of sand–fines mixtures and reveal the underlying microscopic mechanical mechanisms, this study takes sand–fines mixtures composed of natural river sand and silt as the research object.
Kejia Wu, Bing Lv, Hexige Baoyin, Dongsheng Li, Zhouyi Yan, Pengqiang Yu, Yang Liu   +6 more
openaire   +2 more sources

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

Analysis of the start-up mechanism of moraine debris flow based on flume test:A case study of the Aierkuran Gully along the Sino-Pakistan highway

Zhongguo dizhi zaihai yu fangzhi xuebao, 2021
Debris flow caused by moraine soil startingis very common along the Sino-Pakistan Highway, but in previous studies, the characteristics of moraine soil and its influence on the formation of glacier debris flow is lacking.
Yuanyuan FAN, Ling SONG, Xueli WEI
doaj   +1 more source

Properties and Engineering Influence of Corewall Filter I with Different Fine Particle Contents

IOP Conference Series: Earth and Environmental Science, 2019
Abstract The protection provided by filter I for the corewall constitutes an important safety guarantee for the impervious bodies of corewall dams. In particular, the fine particle content (the content of particles < 0.075 mm in size) of filter I provides a filter protection effect for the corewall.
Zheng Huifeng, Wu Guanye, Chen Yi, Sun Lai, Fu Hua   +4 more
openaire   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source