Results 91 to 100 of about 8,734 (263)

Improvement and probabilistic form of CPT-based liquefaction evaluationmodel in Chinese code

Yantu gongcheng xuebao
The cone penetration test (CPT) is commonly used to evaluate sand liquefaction potential due to its efficiency and reliability. The typical CPT method (Chinese code method) shows unreasonable results in fine-grained and deep soils, and the results are ...
ZHAO Zening 1, 2, DUAN Wei 3, CAI Guojun 2, 4, WU Meng 5, 2, LIU Songyu 2
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

SCORE: Self-Supervised Correspondence Fine-Tuning for Improved Content Representations

ICASSP 2024 - 2024 IEEE International Conference on Acoustics, Speech and Signal Processing (ICASSP)
There is a growing interest in cost-effective self-supervised fine-tuning (SSFT) of self-supervised learning (SSL)-based speech models to obtain task-specific representations. These task-specific representations are used for robust performance on various downstream tasks by fine-tuning on the labelled data.
Meghanani, A., Hain, T.
openaire   +3 more sources

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

A new procedure for characterizing the critical intergranular contact state of non-plastic sand – fines mixed materials

Case Studies in Construction Materials
A key and urgent scientific issue is how to characterize the complex intergranular contact state and mechanical behavior evolution of sand–fines mixed materials and then show how this state contributes to the static and dynamic properties of such ...
Tianzhu Hang, Qi Wu, Zifan Wang, Ke Cheng, Longqi Li, Guoxing Chen   +5 more
doaj   +1 more source

Analysis of the content, extractability and fine structure of arabinoxylan

sponsorship: KU Leuven Fund for Fair Open ...
Lambrechts, Eline, De Bondt, Yamina, Janssen, Frederik, Wouters, Arno, Courtin, Christophe   +4 more
openaire   +2 more sources

Effect of terahertz irradiation on DNA damage repair in living cells

FEBS Open Bio, EarlyView.
We investigated the effect of terahertz (THz) wave irradiation on DNA double‐strand break (DSB) repair in living cells. We found that THz irradiation enhanced DSB repair at specific frequencies, whereas heat treatment inhibited it, indicating that this effect is nonthermal and frequency‐specific.
Yuya Ueno, Shota Yamazaki, Hiromichi Hoshina, Masahiko Harata   +3 more
wiley   +1 more source