Results 81 to 90 of about 8,734 (263)

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Fractional-order plasticity model for sand-silt mixtures

Yantu gongcheng xuebao
The sand-silt mixtures, as common heterogeneous soils, are ubiquitous in nature and geotechnical engineering, and their particle contact state and mechanical properties are significantly affected by the factors such as density, stress level and fines ...
SUN Zengchun 1, 2, LIU Hanlong 2, 3, XIAO Yang 2, 3
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Experimental study on development patterns of volumetric strain and predictive modeling for saturated coral sands

Yantu gongcheng xuebao
The coral sand has better drainage conditions, and the drainage deformation of the saturated coral sand under earthquake and wave loads can easily cause damage to the seabed and nearby structures.
WANG Luyang 1, WU Qi 1, 2, ZHOU Zhenglong 1, ZHANG Xinlei 1, WANG Binghui 3, CHEN Guoxing 1
doaj   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

EFFECT OF BIRCH KRAFT PULP PRIMARY FINES ON BLEACHING AND SHEET PROPERTIES

BioResources, 2010
By removing the primary fines from an oxygen-delignified mill birch pulp, a fiber fraction was obtained having low metals content and no extractives. After DEDeD bleaching the fiber fraction had somewhat higher brightness and better brightness stability ...
Sari Anneli Asikainen, Agneta Fuhrmann, Marjatta Ranua, Leif Robertsén   +3 more
doaj  

Cyclic liquefaction behavior of silty sand considering initial static shear effect: a DEM investigation

Yantu gongcheng xuebao
To gain more insights into the microscopic mechanism of the liquefaction behavior, the particle flow program PFC3D is used to simulate the liquefaction process of silty sands under undrained cyclic loading.
PAN Kun 1 , LI Peipei 1, CAO Yi 2, WU Qixin 3, YANG Zhongxuan 4
doaj   +1 more source

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

Utilization of recycled concrete aggregates mixed with fly ash as the road base materials in Vietnam

Journal of Materials and Engineering Structures
Recycling of construction and demolition waste (CDW) and industrial by-products presents substantial environmental, economic, and social benefits. In developed countries, recycling efforts have been actively promoted for decades, resulting in a high ...
Hong Nam THAI
doaj