Results 41 to 50 of about 84,152 (317)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Phosphatase PTPN22 functions as an adaptor in the mTORC2 complex

EMBO Reports
mTOR (mechanistic target of rapamycin) kinase is a pivotal regulator of cellular growth and metabolism, integrating signals from nutrients and growth factors. It functions through the assembly of two distinct complexes, mTORC1 and mTORC2, which differ in
Keshav Gupta, Nagalakshmi Kommineni, Tanuja Bogadi, Neeraja P Alamuru-Yellapragada, Subbareddy Maddika   +4 more
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Lessons Learned in Generating Ground Truth for Indoor Positioning Systems Based on Wi-Fi Fingerprinting

, 2018
Publisher Copyright: © 2018 Elsevier Inc. All rights reserved.Wi-Fi fingerprinting, a well-established indoor positioning technique, relies on a simple rule: the position attached to a fingerprint can be estimated from known positions of similar ...
Puertas-Cabedo, Adrián, Germán M. Mendoza-Silva, Mauri Benedito-Bordonau, Joaquín Huerta, Huerta, Joaquín, Andrea Calia, Adrián Puertas-Cabedo, Joaquín Torres-Sospedra, Luis E. Rodríguez-Pupo, Óscar Belmonte-Fernández, Torres-Sospedra, Joaquín, Montoliu, Raul, Mendoza-Silva, Germán M., Calia, Andrea, Benedito-Bordonau, Mauri, Raul Montoliu, Belmonte-Fernández, Óscar, Trilles, Sergio, Sergio Trilles, Rodríguez-Pupo, Luis E.   +19 more
core   +1 more source

Tuberculosis transmission attributable to close contacts and HIV status, Malawi. [PDF]

, 2006
We conducted the first molecular study of tuberculosis (TB) to estimate the role of household contact and transmission from HIV-positive putative source contacts (PSCs) in a high HIV-prevalence area.
Yates, Malcolm D, Traore, Hamidou, Judith R. Glynn, Hamidou Traore, Michael Mwenebabu, Fine, Paul E.M., Glynn, Judith R., Mwenebabu, M, Glynn, Judith R, Crampin, Amelia C, Mwenebabu, Michael, Mwaungulu, Lorren, Drobniewski, FD, Amelia C. Crampin, Mwaungulu, L, Sian Floyd, Fine, Paul EM, Traoré, H, Paul E.M. Fine, Crampin, Amelia C., Chaguluka, SD, Floyd, Sian, Yates, Malcolm D., Chaguluka, Steven D, Lorren Mwaungulu, Steven D. Chaguluka, Malcolm D. Yates, Drobniewski, Francis, Glynn, JR, Yates, MD, Crampin, AC, Chaguluka, Steven D., Francis Drobniewski, Fine, PEM, Floyd, S   +34 more
core   +1 more source

Developing high-efficiency base editors by combining optimized synergistic core components with new types of nuclear localization signal peptide

Crop Journal, 2020
The clustered regularly interspaced short palindromic repeats (CRISPR)–CRISPR-associated protein (Cas) system has been widely used for genome editing. In this system, the cytosine base editor (CBE) and adenine base editor (ABE) allow generating precise ...
Feipeng Wang, Chengwei Zhang, Wen Xu, Shuang Yuan, Jinling Song, Lu Li, Jiuran Zhao, Jinxiao Yang   +7 more
doaj   +1 more source

What Do Large Language Models Know About Materials?

Advanced Engineering Materials, EarlyView.
If large language models (LLMs) are to be used inside the material discovery and engineering process, they must be benchmarked for the accurateness of intrinsic material knowledge. The current work introduces 1) a reasoning process through the processing–structure–property–performance chain and 2) a tool for benchmarking knowledge of LLMs concerning ...
Adrian Ehrenhofer, Thomas Wallmersperger, Gianaurelio Cuniberti   +2 more
wiley   +1 more source

Only Pay for What You Leak: Leveraging Sandboxes for a Minimally Invasive Browser Fingerprinting Defense

, 2023
We present Sandcastle, an entropy-based browser fingerprinting defense that aims to minimize its interference with legitimate web applications. Sandcastle allows developers to partition code that operates on identifiable information into sandboxes to ...
Torok, Ryan Daniel
core  

Direct Metal Deposition of Graphene–Ti28Nb35.4Zr Matrix Composites With Enhanced Mechanical, Corrosion, and Biocompatibility Properties for Bone Implants

Advanced Engineering Materials, EarlyView.
Graphene nanoplatelet (0.1 wt.%) reinforcement significantly enhances the performance of β Ti‐28Nb‐35.4Zr alloy. Grain refinement, reduced water contact angle, and improved surface characteristics promote osteoblast adhesion and complete surface coverage after 7 days.
Khurram Munir, Jixing Lin, Yuncang Li, Li Zhu, Paul F. A. Wright, Cuie Wen   +5 more
wiley   +1 more source

Transcriptome Analysis Reveals Key Players in Plant Immunity Triggered by Diffusible Signal Factor (DSF), a Xanthomonas-Secreted Quorum-Sensing Molecule

Molecular Plant-Microbe Interactions
Plants are constantly exposed to diverse pathogens and have evolved sophisticated defense mechanisms to detect and respond to microbial threats. Pathogen recognition is often mediated by pathogen-associated molecular patterns (PAMPs), such as cell wall ...
Durga Bhavani KB, Dayakar Boddupally, Kamal K. Malukani, Gokulan CG, Yasobanta Padhi, Hitendra K. Patel, Subhadeep Chatterjee   +6 more
doaj   +1 more source