Results 51 to 60 of about 188,722 (290)
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Multiplex nucleotide editing by high-fidelity Cas9 variants with improved efficiency in rice
BMC Plant Biology, 2019 Background Application of the CRISPR/Cas9 system or its derived base editors enables targeted genome modification, thereby providing a programmable tool to exploit gene functions and to improve crop traits.
Wen Xu +7 more
doaj +1 more source
k-fingerprinting: a Robust Scalable Website Fingerprinting Technique [PDF]
, 2016 Website fingerprinting enables an attacker to infer which web page a client is browsing through encrypted or anonymized network connections. We present a new website fingerprinting technique based on random decision forests and evaluate performance over ...
Danezis, George, Hayes, Jamie
core +1 more source
, 2009 Dark energy perturbations are normally either neglected or else included in a purely numerical way, obscuring their dependence on underlying parameters like the equation of state or the sound speed. However, while many different explanations for the dark
C. Wetterich +6 more
core +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Phosphatase PTPN22 functions as an adaptor in the mTORC2 complex
EMBO ReportsmTOR (mechanistic target of rapamycin) kinase is a pivotal regulator of cellular growth and metabolism, integrating signals from nutrients and growth factors. It functions through the assembly of two distinct complexes, mTORC1 and mTORC2, which differ in
Keshav Gupta +4 more
doaj +1 more source
Asymptotics of Fingerprinting and Group Testing: Capacity-Achieving Log-Likelihood Decoders [PDF]
, 2014 We study the large-coalition asymptotics of fingerprinting and group testing, and derive explicit decoders that provably achieve capacity for many of the considered models. We do this both for simple decoders (fast but suboptimal) and for joint decoders (
Laarhoven, Thijs
core +3 more sources
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Crop Journal, 2020 The clustered regularly interspaced short palindromic repeats (CRISPR)–CRISPR-associated protein (Cas) system has been widely used for genome editing. In this system, the cytosine base editor (CBE) and adenine base editor (ABE) allow generating precise ...
Feipeng Wang +7 more
doaj +1 more source
Towards joint decoding of binary Tardos fingerprinting codes [PDF]
, 2011 The class of joint decoder of probabilistic fingerprinting codes is of utmost importance in theoretical papers to establish the concept of fingerprint capacity. However, no implementation supporting a large user base is known to date.
Furon, Teddy, Meerwald, Peter
core +5 more sources