Results 21 to 30 of about 23,963 (194)

Aligned Fingolimod-Releasing Electrospun Fibers Increase Dorsal Root Ganglia Neurite Extension and Decrease Schwann Cell Expression of Promyelinating Factors

Frontiers in Bioengineering and Biotechnology, 2020
Researchers are investigating the use of biomaterials with aligned guidance cues, like those provided by aligned electrospun fibers, to facilitate axonal growth across critical-length peripheral nerve defects. To enhance the regenerative outcomes further,
Devan L. Puhl, Devan L. Puhl, Jessica L. Funnell, Jessica L. Funnell, Anthony R. D’Amato, Anthony R. D’Amato, Jonathan Bao, Jonathan Bao, Dmitri V. Zagorevski, Yelena Pressman, Daniel Morone, Daniel Morone, Agnes E. Haggerty, Martin Oudega, Martin Oudega, Martin Oudega, Martin Oudega, Ryan J. Gilbert, Ryan J. Gilbert   +18 more
doaj   +1 more source

The emerging role of FTY720 (Fingolimod) in cancer treatment [PDF]

, 2016
FTY720 (Fingolimod) is a clinically approved immunomodulating therapy for multiple sclerosis that sequesters T-cells to lymph nodes through functional antagonism of sphingosine-1-phosphate 1 receptor.
Abdollahi, Alewijnse, Alexander, Aradhye, Arai, Arlinghaus, Bae, Baumruker, Baxter, Ben-Sasson, Bohler, Bollen, Braun, Brinkmann, Broek, Brune, Brune, Bueno, Bueno, Bueno, Burtin, Byrd, Cabot, Campochiaro, Chauhan, Chen, Chiba, Curino, Cuvillier, Cuvillier, Cuvillier, Cuvillier, Cuvillier, Cuvillier, Cuvillier, Cuvillier, Cuvillier, Cuvillier, Cuvillier, Cuvillier, Cyster, Cyster, Edwards, Eshhar, Fan, Fan, Fan, Fan, Ferrer, Gajewski, Garcia, Garcia-Foncillas, Garcia-Foncillas, Geilen, Grech, Greten, Habib, Hahn, Hakomori, Hakomori, Hakomori, Han, Han, Hanessian, Hannun, Hannun, He, Hla, Hla, Hla, Hla, Hla, Hla, Hla, Hla, Hla, Hoshino, Huang, Huwiler, Huwiler, Huwiler, Huyton, Ibrahim, Igarashi, Igarashi, Igarashi, Jaffrezou, Kappos, Karliner, Karliner, Kasahara, Katsuoka, Katsuoka, Katsuoka, Kaufmann, Klostergaard, Kohama, Kordula, Kornblau, Lee, Lee, Lei, Lei, Li, Liao, Lichter, Liu, Liu, Liu, Lynch, Lynch, Lynch, Macdonald, Marcucci, Masood, Matsuyama, May, May, Moolenaar, Morisaki, Mosser, Muthusamy, Muthusamy, Muthusamy, Nakamura, Neviani, Neviani, Nozawa, Nozawa, Nussbaumer, Obeid, Obeid, Obeid, Obeid, Oberlies, Odero, Ogretmen, Ohdan, Okumoto, Okuyama, Park, Pchejetski, Pchejetski, Phelps, Pitson, Pitson, Pitson, Pollard, Prior, Proia, Proia, Pyne, Pyne, Pyne, Pyne, Pyne, Pyne, Rader, Radue, Rennard, Rodrigues, Rosen, Rosen, Roy, Ruefli-Brasse, Sabbadini, Sakaguchi, Sanchez, Satoh, Schmouder, Schwartz, Seishima, Sharma, Shinomiya, Shinomiya, Shinomiya, Shinomiya, Shinomiya, Smith, Smith, Song, Song, Spiegel, Spiegel, Spiegel, Spiegel, Spiegel, Spiegel, Spiegel, Spiegel, Spiegel, Spiegel, Spiegel, Spiegel, Spiegel, Spiegel, Spiegel, Spiegel, Spiegel, Spiegel, Spiegel, Spiegel, Stracke, Stracke, Stracke, Sun, Suzuki, Suzuki, Tagliaferri, Tagliaferri, Takahara, Takuwa, Takuwa, Taniwaki, Tornquist, Troncone, Uesato, Vadas, Vadas, Vadas, Vadas, Verrills, Walsh, Wang, Wang, Wattenberg, Wattenberg, Waxman, Weichselbaum, Wiedermann, Wolf, Wong, Wong, Wood, Woodcock, Wu, Xia, Xia, Xia, Xia, Xu, Xu, Yap, Yee, Yun, Yun, Zangemeister-Wittke, Zawadzke, Zheng, Zheng   +249 more
core   +2 more sources

Induced Stem Cells as a Novel Multiple Sclerosis Therapy. [PDF]

, 2016
Stem cell replacement is providing hope for many degenerative diseases that lack effective therapeutic methods including multiple sclerosis (MS), an inflammatory demyelinating disease of the central nervous system. Transplantation of neural stem cells or
Guan, Yang-Tai, Liu, Yan-Qun, Xie, Chong, Zhang, Guang-Xian   +3 more
core   +2 more sources

Fingolimod Inhibits Inflammation but Exacerbates Brain Edema in the Acute Phases of Cerebral Ischemia in Diabetic Mice

Frontiers in Neuroscience, 2020
Background and Purpose: Diabetes mellitus increases stroke incidence and mortality and hampers functional recovery after stroke. Fingolimod has been shown to improve neurofunctional recovery and reduce brain infarction after ischemic injury in mice ...
Wanlu Li, Tingting He, Tingting He, Lu Jiang, Rubing Shi, Yaying Song, Yaying Song, Muyassar Mamtilahun, Yuanyuan Ma, Yuanyuan Ma, Zhijun Zhang, Yaohui Tang, Guo-Yuan Yang, Guo-Yuan Yang, Yongting Wang   +14 more
doaj   +1 more source

The effect of fingolimod on regulatory T cells in a mouse model of brain ischaemia

Journal of Neuroinflammation, 2021
Background The role of the immune system in stroke is well-recognised. Fingolimod, an immunomodulatory agent licensed for the management of relapsing-remitting multiple sclerosis, has been shown to provide benefit in rodent models of stroke.
Kyle Malone, Andrea C. Diaz Diaz, Jennifer A. Shearer, Anne C. Moore, Christian Waeber   +4 more
doaj   +1 more source

Fingolimod treatment promotes proliferation and differentiation of oligodendrocyte progenitor cells in mice with experimental autoimmune encephalomyelitis

Neurobiology of Disease, 2015
Multiple sclerosis (MS) is a major demyelinating disease of the central nervous system (CNS) leading to functional deficits. The remyelination process is mediated by oligodendrocyte progenitor cells (OPCs).
Jing Zhang, Zheng Gang Zhang, Yi Li, Xiaoshuang Ding, Xia Shang, Mei Lu, Stanton B. Elias, Michael Chopp   +7 more
doaj   +1 more source

Cardiovascular effects of fingolimod: Relevance, detection and approach

Revista Portuguesa de Cardiologia, 2015
Fingolimod, a structural analogue of sphingosine, is the first oral treatment available for multiple sclerosis. The presence of sphingosine-1-phosphate receptors in the sinus and atrioventricular nodes, myocardial cells, endothelial cells and arterial ...
Carlos Aguiar, Sónia Batista, Ricardo Pacheco   +2 more
doaj   +1 more source

Targeting synaptic pathology in multiple sclerosis: fingolimod to the rescue? [PDF]

, 2012
Multiple sclerosis (MS) is an inflammatory disorder affecting the brain and spinal cord. Major hallmarks of MS typically include inflammation, demyelination and axon degeneration, although recent studies have also implicated synaptic dysfunction and ...
Brinkmann, Centonze, Cohen, Coleman, Compston, Dutta, Fischer, Hensley, Khatri, Mandolesi, Murray, Papadimitriou, Pitt, Rossi, Smith, Sriram, Wishart, Zhu   +17 more
core   +1 more source

Effects of fingolimod on heart injury induced by renal ischemia-reperfusion [PDF]

مجله پزشکی دانشگاه علوم پزشکی تبریز
Background. Renal ischemia-reperfusion injury (IRI) is one of the inevitable complications of surgery. The evidence shows that fingolimod, with its anti-inflammatory effects, can play a protective role in renal IRI.
Bahram Niknafs, Yasin Bagheri, Seyyedeh Mina Hejazian, Parya Niknafs, Neda Roshanravan, Mohammadreza Ardalan, Sepideh Zununi Vahed   +6 more
doaj   +1 more source

18F-FAC PET Visualizes Brain-Infiltrating Leukocytes in a Mouse Model of Multiple Sclerosis. [PDF]

, 2020
Brain-infiltrating leukocytes contribute to multiple sclerosis (MS) and autoimmune encephalomyelitis and likely play a role in traumatic brain injury, seizure, and stroke.
Chen, Bao Ying, Clark, Peter M, Ghezzi, Chiara, Quon, Andrew, Radu, Caius G, Villegas, Brendon, Witte, Owen N   +6 more
core   +1 more source