Results 61 to 70 of about 8,525 (308)
Cogent Engineering, 2018 High precision parts have been widely used in automobile, aerospace, medical and other fields. Conventional machining methods are difficult to meet the requirements of the high-quality requirements of components, including shape precision, dimensional ...
Tang Dewen, Peng Cong, Zhang Jiayu
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Elid superfinishing of spherical bearings [PDF]
, 2007 Driven by a requirement to extend the lifespan of self-aligning lined spherical bearings, this research investigates the use of Elid (electrolytic in-process dressing) as a method of improving ball surface finish.
Raffles, Mark H.
core
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
FINISH-MACHINING STRATEGIES FOR BLADED DISKS [PDF]
, 2022 Integrally Bladed Rotors (IBRs) or Bladed Disks (Blisks) are strategic components of compressor or turbine stages of aircraft engines. Development of manufacturing techniques and materials have aided the integration of two components, blades and the disk,
Arrospide Garro, Iraitz
core
, 2022 Parameters used in laser powder bed fusion (LPBF) process are key factors that influence the surface integrity and thus mechanical properties of Inconel 718 components fabricated by additive manufacturing (AM) technique.
core +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
HeliyonThis study investigates the optimization of cutting conditions for machining titanium alloy (Ti-6Al-4V) using Response Surface Methodology (RSM), with the goal of minimizing tool-chip interface temperature and surface roughness.
Shazzad Hossain +4 more
doaj +1 more source