Results 71 to 80 of about 8,525 (308)
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Robotic edge machining with abrasive brushes
MATEC Web of Conferences, 2018 The article describes application of an industrial robot with an electric spindle for finish machining of parts made from aluminum alloy V95pchT2 and titanium alloy VT-20 using abrasive brushes.
Dimov Yuriy, Podashev Dmitriy
doaj +1 more source
Retained Austenite Control for the Soft Machining of High-Hardness Tool Steels
Metals, 2018 Most high-hardness tool steels comprising forming dies require expensive finish machining operations to compensate for the dimensional distortion and surface oxidation caused by the die heat treatment.
Maider Muro +4 more
doaj +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
1Simulation and experimental research on multi-pass cutting of nickel-based alloy by WEDM-LS
AIP AdvancesWire Electrical Discharge Machining-Low Speed (WEDM-LS) offers high precision and flexibility for machining nickel-based alloys but is limited to aerospace applications due to surface property degradation caused by the recast layer.
Xin Wu +5 more
doaj +1 more source
Applied SciencesMachining efficiency and stability are crucial for achieving high-quality manufacturing outcomes. One of the primary challenges in machining is the suppression of chatter, which negatively impacts surface finish, tool longevity, and overall process ...
Yu-Peng Yeh +2 more
doaj +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Al-Khawarizmi Engineering Journal, 2019 The surface finish of the machining part is the mostly important characteristics of products quality and its indispensable customers’ requirement. Taguchi robust parameters designs for optimizing for surface finish in turning of 7025 AL-Alloy using ...
Safaa K. Ghazi +3 more
doaj
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
STL-based Finish Machining of Rapid Manufacturing Parts and Tools [PDF]
, 2001 Accuracy and surface quality problems when utilizing layered manufacturing technologies have limited its use in tooling areas. Therefore, in some situations a CNC machine is still necessary for finish machining of rapid manufactured parts and tools ...
Qu, Xiuzhi, Stucker, Brent E.
core +1 more source