Results 71 to 80 of about 7,637,178 (292)
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
A Condition for a Finite Group to be Cyclic [PDF]
Proceedings of the American Mathematical Society, 1972 A finite group, with the property that for every prime power q =pk there are at most pk+l -1 elements in the group whose qth power is the identity, is a cyclic group. It seems to be well known that a finite group, which need not be given to be abelian, must be cyclic if for every positive integer n, the number of elements for which Xn is the identity ...
openaire +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Image restoration using a discrete point spread function with consideration of finite pixel size
Российский технологический журналObjectives. The problem of restoring defocused and/or linearly blurred images using a Tikhonov-regularized inverse filter is considered. A common approach to this problem involves solving the Fredholm integral equation of the first convolution type by ...
Victor B. Fedorov +2 more
doaj +1 more source
Generic Finiteness of Outcome Distributions for Two Person Game Forms with Three Outcomes [PDF]
Generic finiteness; game forms; Nash ...
Carlos Pimienta
core
Finiteness conditions for the box-tensor product of groups and related constructions
, 2021 We study finiteness conditions and closure properties for the box-tensor product G⊠H and related constructions. The content of this paper extends some results concerning the non-abelian tensor product of groups G⊗H.
Bastos, Raimundo +2 more
core +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source