Results 81 to 90 of about 7,637,178 (292)

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Tame complexity of effective field theories in the quantum gravity landscape

Journal of High Energy Physics
Effective field theories consistent with quantum gravity obey surprising finiteness constraints, appearing in several distinct but interconnected forms.
Thomas W. Grimm, David Prieto, Mick van Vliet   +2 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

ACCOUNTING OF INSTRUMENTAL ERRORS IN THE CONTROL OF WINDINGS OF ELECTRICAL MACHINES WITH THE USE OF QUASI-PERIODIC TEST SIGNALS

Известия высших учебных заведений и энергетических объединенний СНГ: Энергетика, 2018
The solution of problems of diagnostics of windings of electric machines is associated with the necessity of selection of quasi-periodic test signals against the background noise.
A. A. Sheinikov, Yu. V. Suchodolov, V. V. Zelenko   +2 more
doaj   +1 more source

Finiteness and iteration conditions for semigroups

Theoretical Computer Science, 1991
The article investigates iteration conditions of regular and finitely generated semigroups. Let \(S\) be a semigroup and \(m\) and \(n\) two integers such that \(m>0\) and \(n\geq 0\). We say that \(S\) verifies the iteration property \(C(n,m)\) if the following condition is verified: For any sequence \(s_ 1,s_ 2,\dots,s_ m\) of \(m\) elements of \(S\)
DE LUCA, ALDO, S. VARRICCHIO
openaire   +4 more sources

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

The unitary architecture of renormalization

Journal of High Energy Physics
We set up a bootstrap problem for renormalization. Working in the massless four-dimensional O(N) model and the λϕ 4 theory, we prove that unitarity leads to all-loop recursion relations between coefficients of scattering amplitudes with different ...
Ameya Chavda, Daniel McLoughlin, Sebastian Mizera, John Staunton   +3 more
doaj   +1 more source

Geometric and homotopy theoretic methods in Nielsen coincidence theory

Fixed Point Theory and Applications, 2006
In classical fixed point and coincidence theory, the notion of Nielsen numbers has proved to be extremely fruitful. Here we extend it to pairs (f1,f2) of maps between manifolds of arbitrary dimensions.
Ulrich Koschorke
doaj   +1 more source