Results 101 to 110 of about 10,045,153 (250)

Decoding the Neural Circuit Underlying Context‐Cue Association in Retrieval of Morphine Reward Memory

Advanced Science, EarlyView.
Contextual cues recruit the glutamatergic vCA1–dmPFC pathway to retrieve morphine reward memory by reshaping cell‐type‐specific prefrontal microcircuit activity. Distinct regulation of PV+ and SST+ interneurons defines this hippocampal–prefrontal mechanism.
Zhifeng Shi, Guangying Li, Qian Yang, Rusun Liu, Linghan Gu, Mingmei Wang, John L. Waddington, Fuhai Ji, Xuechu Zhen   +8 more
wiley   +1 more source

Fire Risk Assessment in Hotels and Resorts Using FRAME (A case study of four-star hotels in Mashhad)

بهداشت کار و ارتقای سلامت, 2017
Introduction: Fire has devastating fatal, financial, and environmental consequences for the community, and there are many victims annually in different societies.
Meysam REZAEE, Saeed GIVEHCHI, Mahnaz NASRABADI   +2 more
doaj  

Blockchain for fire-risk reduction in long-scale tunnel construction

Journal of Civil Engineering and Management
Tunnel construction fire risk reduction is an integral component for tunnel construction safety. Recent fire cases during tunnel construction illustrate how existing management and prevention measures may fail in a fundamental and critical guarantee in ...
Hongwei Huang, Sihan Liu, Liqing Qu, Xiaofeng Ma   +3 more
doaj   +1 more source

An Extracellular Pore‑Targeting Peptide Defines a Designable Allosteric Site in TRPV2

Advanced Science, EarlyView.
Structure‐guided peptide engineering yields Depiv2, a highly potent and subtype‐selective TRPV2 inhibitor that binds to the extracellular pore and remodels it into a closed, non‐conductive state. Depiv2 suppresses pathological cardiac hypertrophy, establishing the TRPV2 outer pore as a designable interface for selective peptide modulation.
Aiqin Zhu, Hongkun Wang, Jiawei Wang, Xiaolu Liu, Aerziguli Aierken, Lizhen Xu, Ping Liang, Fan Yang   +7 more
wiley   +1 more source

Optimal Forest Rotations with Environmental Values and Endogenous Fire Risk [PDF]

This paper develops a model that solves for the optimal economic harvest rotation problem to maximize revenue of an even-aged forest plantation when there is a risk of a catastrophic forest fire.
Daigneault, Adam J., Sohngen, Brent, Miranda, Mario J.   +2 more
core  

Fire/Explosion Risk Assessment and Loss Prevention of Hazardous Materials, Mines and Natural Gas

This reprint compiles cutting-edge research and insights from the Special Issue "Fire/Explosion Risk Assessment and Loss Prevention of Hazardous Materials, Mines, and Natural Gas." It addresses critical challenges in managing and mitigating risks ...

core   +1 more source

Co‐activation of Selective Nicotinic Acetylcholine Receptor Subtypes Is Required for Neuroprotection against Alzheimer's Disease

Advanced Science, EarlyView.
ABSTRACT Beta‐amyloid peptide (Aβ)‐induced suppression of hippocampal GABAergic interneuron activity drives hyperexcitability, amyloid pathology, and cognitive impairment in Alzheimer's disease (AD), suggesting that enhancing hippocampal inhibition may be protective.
Rahmi Lee, Gayeon Kim, Ellison R. Black, Seonil Kim   +3 more
wiley   +1 more source

Retrospective Grid Cells in the Medial Entorhinal Cortex Encode Past Paths During Spatial Navigation

Advanced Science, EarlyView.
Retrospective grid cells are identified in the medial entorhinal cortex, with spatial firing patterns that become most grid‐like when activity is projected onto recently traversed locations. Their coding loses spatial precision in darkness and is disrupted during assisted movement, indicating that entorhinal representations incorporate recent path ...
Ruojin Liu, Xin Yuan, Zilong He, Hong Jin, Jiayi Tian, Cong Chen, Yuanjing Liu, Xiang Zhang, Shidan Wen, Emilio Kropff, Chenglin Miao   +10 more
wiley   +1 more source

Cannabinoid CB1 Receptor in Nociceptors Mediates Postoperative Analgesia via ASIC3 Inhibition

Advanced Science, EarlyView.
CB1R and ASIC3 are co‐expressed in CGRP+ nociceptors of mouse DRG. Plantar incision triggers an upregulation of ASIC3 and activation of ASIC3+ neurons, driving mechanical allodynia. CB1R activation suppresses ASIC3 function and downstream ERK1/2 phosphorylation, thereby braking nociceptive signaling and accelerating pain resolution.
Kangtai Xu, Luyao Ji, Haoyi Yang, Xiying Chen, Qiaodan Hu, Haimei He, Jiawei Wu, Leyan Shan, Shihui Feng, Yingzhi Li, Xiongchang Tan, Hao Wang, Zilong Wang, Chaoran Wu   +13 more
wiley   +1 more source

Evacuation Route Determination in Indoor Architectural Environments Based on Dynamic Fire Risk Assessment

Buildings
The enclosed nature of indoor building spaces during fires creates complex fire environments and restricted evacuation routes, substantially elevating the risk of mass casualties.
Jiaojiao Bai, Xikui Lv, Liangtao Nie, Mingjing Fang   +3 more
doaj   +1 more source