Results 121 to 130 of about 10,045,153 (250)

A Spatiotemporal Single‐Cell Atlas Uncovers Dysregulated ECM Dynamics and Septal Remodeling Arrest in Human Ventricular Septal Defects

Advanced Science, EarlyView.
Integrating single‐cell and spatial transcriptomics reveals human ventricular septal defect (VSD) as a disease of microenvironmental insufficiency and structural remodeling arrest. Attenuated endothelial‐fibroblast crosstalk, alongside downregulated THBS1/TGF‐β1 and MMP2 signaling networks, impairs the endothelial‐to‐mesenchymal transition (EndoMT) and
Xiaoyuan Zhang, Lun Zhu, Ze Sun, Ruolin Jia, Ziming Wang, Jiayao Zhao, Bohao Liu, Haiqing Xiong, Xiaowei Yu, Yanzhu Yue   +9 more
wiley   +1 more source

Dynamic modeling and real-time risk assessment of tunnel fires using pressure-state-response (PSR)-enhanced bayesian network

Results in Engineering
Tunnel fires present complex and evolving scenarios owing to confined geometries, limited ventilation, and high traffic density; this often results in severe casualties and significant economic losses.
Yingzhi Zhang, Long Chen, Yuke Shi, Haiying Wang   +3 more
doaj   +1 more source

Drug Repurposing for Treating NCOR‐Related Intellectual Disability

Advanced Science, EarlyView.
An autism‐associated NCOR1 heterozygous mutation upregulates NRGs and activates NRG backward signaling in hypothalamic GABAergic neurons in mouse models, leading to Gabra2 downregulation and cognitive deficits, which can be therapeutically targeted by repurposing FDA‐approved drugs.
Yan Kong, Wenjun Zhou, Yuxiang Sun, Zihan Huang, Zhiyue Liu, Udhaya Kumar. S, Chenyan Li, Yi Lu, Chengchuang Song, Veronica C. Ciliberto, Makenna Mack, Lana E. Kim, Zhaoyong Hu, Fang Luo, Aihua Cao, Zheng Sun   +15 more
wiley   +1 more source

In Situ Photo‑Crosslinked Functional Bilayer Hydrogel Modulates Local Microenvironment and Remyelination After Optic Nerve Injury

Advanced Science, EarlyView.
A blue‐light‐crosslinked bilayer hydrogel was developed for local optic nerve repair. The adhesive GM‐Odex outer layer seals and anchors the lesion, while the non‐adhesive GM‐imid inner layer releases MPDA‐Cle without obstructing CSF flow. This system modulates oxidative and inflammatory microenvironments, supports oligodendrocyte differentiation and ...
Tonghe Pan, Yate Huang, Junhao Zhang, Shudong Tian, Zhixing Li, Xuanwen Li, Yanchen Zhang, Dongmei Wang, Sihao Ye, Ming Jin, Neng Ling, Wentao Yan, Kaihui Nan, Wencan Wu   +13 more
wiley   +1 more source

A Machine Learning Framework for Fire Risk Prediction With Response and Proximity Insights

IEEE Access
Advances in artificial intelligence (AI) and machine learning (ML) have significantly enhanced fire risk assessment by enabling predictive analytics, real-time decision support, and optimized emergency response. Accurate fire risk assessments are crucial
Dilli Prasad Sharma, Nasim Beigi-Mohammadi, Praveen Soni, Rob Madro, Phil Emmenegger, Carlos Tobar, Jeff Li, Alberto Leon-Garcia   +7 more
doaj   +1 more source

Connecticut State Fire Safety Code (2018); Other title: Connecticut state fire safety code

, 2018
Effective October 1, 2018.; Title from cover.; Based on the 2015 editions of the ICC Fire Code and NFPA 101, Life Safety Code.; "The Connecticut State Fire Safety Code shall be administered as provided in chapter 541 of the Connecticut General Statutes"-
Connecticut. Office of the State Fire Marshal,
core  

Fire‐Safe Hierarchical Solid Polymer Electrolytes Enabled by Dual‐Functional Microcapsules for Lithium Metal Batteries

Advanced Science, EarlyView.
Dual‐functional fire‐safe microcapsules are integrated into hierarchical solid polymer electrolytes to provide sequential protection against thermal abuse. The ammonium hydrogen phytate‐modified shell forms a protective char barrier, while the thermally triggered release of perfluoro(2‐methyl‐3‐pentanone) actively suppresses combustion, enabling safer ...
Ziqi Huang, Jiuqing Gui, Qiaoying Cao, Yong Xiao, Hang Hu, Yeru Liang   +5 more
wiley   +1 more source

Planning an Automatic Fire Detection, Alarm, and Extinguishing System for Research Laboratories

Muhandisī-i bihdāsht-i ḥirfah/ī, 2014
Background & Objectives: Educational and research laboratories in universities have a high risk of fire, because they have a variety of materials and equipment.
Rostam Golmohamadi, Iraj Mohamadfam, Masoud Shafiee Motlagh, Ebrahim Darvishi, Akram Mortezaie, Faeze Azizian   +5 more
doaj  

Remote sensing diagnosis of Forest fire risk based on state-trend characteristics using machine learning models

Ecological Indicators
Forest fires rank among the primary natural disasters threatening the ecological security of the Greater Khingan Range region, making the precise diagnosis of fire risk factors crucial for fire prevention and control. This study proposes a remote sensing
Xiaotong Gao, Chunxiang Cao, Shaohua Wang, Min Xu, Jingbo Li, Xinwei Yang, Yujie Yang, Ruichen Hu, Yu Zhang, Shihong Wu, Xinchi Guan, Jiahui Ji   +11 more
doaj   +1 more source

Risk factors and risk assessment in juvenile fire-setting

, 2011
This article provides an overview of the literature on risk issues in juvenile fire-setting behaviour. In particular, we highlight the importance of acknowledging the differences in terminology used in current studies and outline the importance of ...
Fritzon, Katarina, Mairead Dolan, Troy E. McEwan, Doley, Rebekah, Dolan, Mairead, Katarina Fritzon, McEwan, Troy E., Rebekah Doley   +7 more
core   +1 more source