Results 91 to 100 of about 223,438 (303)

Tailoring Vascular‐Immune Homeostasis via Manganese‐DNA Complex‐Armed Immunogenic Extracellular Vesicles for Pancreatic Cancer Immunotherapy

open access: yesAdvanced Science, EarlyView.
This study demonstrates that Mn2⁺–tumor DNA complexes encapsulated in dendritic cell (DC)– derived immunogenic extracellular vesicles (EVDC@Mn‐DNA) act as a DC‐specific cGAS– STING activator. EVDC@Mn‐DNA treatment enhances intratumoral DC activation, improves tumor vascular function, promotes CD8⁺ T cell activity, and suppresses pancreatic tumor growth,
Xue Jiang   +13 more
wiley   +1 more source

Wildfire management in Mediterranean-type regions: paradigm change needed

open access: yesEnvironmental Research Letters, 2020
During the last decades, climate and land use changes led to an increased prevalence of megafires in Mediterranean-type climate regions (MCRs). Here, we argue that current wildfire management policies in MCRs are destined to fail.
Francisco Moreira   +21 more
doaj   +1 more source

A Collaborative Approach for Reducing Wildland Fire Risks to Communities and the Environment [PDF]

open access: yes
The Secretaries of Agriculture and the Interior joined the Western Governors' Association, National Association of State Foresters, National Association of Counties, and the Intertribal Timber Council to endorse this 10-Year Comprehensive Strategy to ...

core  

Mode competition in superradiant scattering of matter waves

open access: yes, 2011
Superradiant Rayleigh scattering in a Bose gas released from an optical lattice is analyzed with incident light pumping at the Bragg angle for resonant light diffraction.
Chen, Xuzong   +5 more
core   +1 more source

Piezo2 Mediates a Vicious Cycle of “Mechanical Homeostasis Imbalance—Inflammation” in Sensory Nerves and the Cartilage Endplate

open access: yesAdvanced Science, EarlyView.
In a lumbar spine instability model, dorsal root ganglion cells mediate the perception of relevant mechanical stresses through Piezo2 and subsequently release CGRP. CGRP activates the NF‐κB signaling pathway in cartilage endplate cells through the receptor RAMP1.
Hanpeng Xu   +16 more
wiley   +1 more source

Profiles of fire suppression contracting businesses [PDF]

open access: yes, 2016
2 pagesFederal agencies are increasingly relying on contracts to respond to wildfire. Although present since the 1970s, private equipment contractors have come to play an important role following extreme fire seasons in the 1990s.
Ellison, Autumn   +4 more
core  

Neuid: A Novel Neuron‐Enriched LncRNA that Connects Epigenetic Gene Silencing to Alzheimer's Disease

open access: yesAdvanced Science, EarlyView.
ABSTRACT The increasing evidence that non‐coding RNAs can become deregulated during pathogenesis is dramatically expanding the space for drug discovery beyond the protein‐coding genome. Long noncoding RNAs (lncRNAs) are emerging as key regulators of cellular function, yet most remain uncharacterized.
Ranjit Pradhan   +17 more
wiley   +1 more source

Posture Evaluation of Firefighters During Simulated Fire Suppression Tasks. [PDF]

open access: yesWorkplace Health Saf, 2023
Kajaks T   +4 more
europepmc   +1 more source

Decorrelation of neural-network activity by inhibitory feedback [PDF]

open access: yes, 2012
Correlations in spike-train ensembles can seriously impair the encoding of information by their spatio-temporal structure. An inevitable source of correlation in finite neural networks is common presynaptic input to pairs of neurons.
Gaute T. Einevoll   +4 more
core   +3 more sources

A Tac1‐Expressing Brainstem Pathway Underlies the Pathogenesis of Trigeminal Neuralgia

open access: yesAdvanced Science, EarlyView.
A critical TG‐Sp5CTac1‐PBNTac1 pathway drives trigeminal neuropathic pain (TNP). Tac1‐expressing parabrachial nucleus (PBNTac1) neurons exhibit heightened responses to innocuous stimuli in TNP, and chemogenetic inhibition of these neurons effectively prevents TNP development.
Liting Sun   +11 more
wiley   +1 more source

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