Results 211 to 220 of about 104,905 (268)

MiR‐146a‐5p Suppresses M1 Polarization of Tumor‐Associated Macrophages via IRAK1/NF‐κB Signaling in Colorectal Polyps

open access: yesAnnals of Gastroenterological Surgery, EarlyView.
MiR‐146a‐5p is downregulated in colorectal polyps, leading to IRAK1 upregulation and NF‐κB activation, which promotes M1 macrophage polarization and inflammation. Overexpression of miR‐146a‐5p suppresses IRAK1/NF‐κB signaling, reduces M1 polarization, and alleviates inflammatory responses.
Peng Song   +6 more
wiley   +1 more source

Automation of Surgical Workflow Recognition: Unveiling the Surgical Instrument Kinematics that Underly Robot‐Assisted Prostatectomy Procedures

open access: yesAdvanced Intelligent Discovery, EarlyView.
Automated procedural analysis is recognized as one of the major game changers for robotic surgery. Meaning digital analysis needs to replace the manual assessments that set todays standard. Mechanical robotic‐instrument tracking enables the derivation of quantitative kinematic metrics that support behavior‐based workflow segmentation into distinct ...
Kateryna Pirkovets   +4 more
wiley   +1 more source

LncRSFD Alternative Splicing Modulates the Proliferation and Differentiation of Adipocytes Through Sponging miRNAs

open access: yesAnimal Research and One Health, EarlyView.
This study identified a molecule named lncRSFD, which is highly expressed in sheep adipose tissues. The lncRSFD gene generates two distinct transcript variants via alternative splicing: lncRSFD‐L and lncRSFD‐S. Functionally, lncRSFD alternative splicing (lncRSFD‐L/S) promotes the proliferation, differentiation, and lipid metabolism of adipocytes ...
Jinpeng Wang   +9 more
wiley   +1 more source

MicroRNA‐Seq Analysis Reveals a Critical Role for miR‐222 in Bovine Intramuscular Adipogenesis via the DDIT4/mTORC1 Axis

open access: yesAnimal Research and One Health, EarlyView.
Schematic diagram illustrating how miR‐222 promotes bovine intramuscular adipogenesis by targeting DDIT4 to activate the mTORC1 signaling pathway. ABSTRACT Intramuscular fat (IMF) is a key determinant of beef quality, particularly with respect to tenderness, flavor, and juiciness.
Jianbing Tan   +7 more
wiley   +1 more source

ZBED6 Knockout Promotes Skeletal Muscle Development in Bama Pigs by Relieving Transcriptional Repression of CDKN1A

open access: yesAnimal Research and One Health, EarlyView.
Integrated transcriptomic and functional analyses identify CDKN1A as a direct target of ZBED6 in Bama pigs. ZBED6 knockout relieves transcriptional repression of CDKN1A, thereby promoting myogenic differentiation and skeletal muscle development.
Yitian Ma   +8 more
wiley   +1 more source

Home - About - Disclaimer - Privacy