Results 71 to 80 of about 104,905 (268)

Genome‐Wide CRISPR Screen Identifies a microRNA Orchestrating Pleiotropic Resistance to Targeted Therapy and T Cell Immunity in Melanoma

open access: yesAdvanced Science, EarlyView.
A genome‐wide microRNA CRISPR screen identifies miR‐18a as a master regulator of cross‐resistance in melanoma. Loss of miR‐18a activates the AJUBA–YAP/Hippo axis to confer BRAFi resistance and enhances THBS1–CD47 interaction to impair CD8+ T cell immunity. hnRNP A1 is identified as an upstream regulator of miR‐18a processing.
Zhao Wang   +19 more
wiley   +1 more source

Firefly revisited: essays on Joss Whedon's classic series [PDF]

open access: yes, 2015
According to Joss Whedon, the creator of the short-lived series Firefly (2002), the cult show is about “nine people looking into the blackness of space and seeing nine different things.” The chronicles of crewmembers on a scruffy space freighter, Firefly

core  

The complete mitochondrial genome of the firefly, Abscondita chinensis (Coleoptera: Lampyridae)

open access: yesMitochondrial DNA. Part B. Resources, 2019
We report the complete mitochondrial genome of Firefly, Abscondita chinensis. The circular genome of 16,309 bp and has a base composition of A (43.63%), C (11.53%), G (8.50%), T (36.31%).
Jialu Wang, Xinhua Fu
doaj   +1 more source

PRMT1‐Mediated LDHA Methylation Drives STAT3 Lactylation to Orchestrate Intestinal Inflammation and Tumorigenesis

open access: yesAdvanced Science, EarlyView.
This study identifies an immunometabolic axis wherein SAM‐driven PRMT1 methylates LDHA, enhancing its activity. The resultant lactate induces STAT3 K709 lactylation, which stabilizes an active conformation to promote STAT3 phosphorylation and IL‐10 expression.
Hui Wang   +12 more
wiley   +1 more source

An Improved Firefly Algorithm with Adaptive Strategies [PDF]

open access: yes, 2012
Firefly Algorithm (FA) is a powerful swarm intelligence algorithm inspired by the flash phenomenon of the fireflies. However, it has weaknesses on optimizing high-dimensional problems.
Zhu YL(朱云龙)   +3 more
core  

Firefly Light Flashing: Oxygen Supply Mechanism [PDF]

open access: yes
Firefly luminescence is an intriguing phenomenon with potential technological applications, whose biochemistry background was only recently established.
Hsu, Su-Ting   +9 more
core   +1 more source

Self-Adaptive Step Firefly Algorithm [PDF]

open access: yes, 2013
In the standard firefly algorithm, each firefly has the same step settings and its values decrease from iteration to iteration. Therefore, it may fall into the local optimum.
Shoubao Su, Shuhao Yu, Shanlin Yang
core   +1 more source

A Novel Classifier based on Firefly Algorithm [PDF]

open access: yes, 2020
During the past decade, assigning objects to one of several predefined classes with higher accuracy has received considerable focus among researchers.
Akram Ibrahim Salah   +3 more
core   +1 more source

An Improved Chromosome-Level Genome Assembly of the Firefly Pyrocoelia pectoralis

open access: yesInsects
The endemic and endangered Chinese firefly Pyrocoelia pectoralis is a sexually dimorphic, nocturnal species. A previous attempt by this team to assemble a draft genome of P.
Xinhua Fu   +3 more
doaj   +1 more source

The complete mitogenome and phylogenetic analysis of Japanese firefly ‘Genji Botaru’ Luciola cruciata (Coleoptera: Lampyridae)

open access: yesMitochondrial DNA. Part B. Resources, 2017
We performed mitogenome analysis of Japanese firefly Luciola cruciata (Coleoptera: Lampyridae), which is unique species in Japan. It is classified into six haplotypes based on the difference of COII sequence on mitochondrial DNA.
Juri Maeda   +5 more
doaj   +1 more source

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