Results 91 to 100 of about 71,446 (289)

Differentiation of Stem Cells from Human Exfoliated Deciduous Teeth into Retinal Photoreceptor-Like Cells and Their Sustainability In Vivo

Stem Cells International, 2019
Retinal degeneration is characterized by the progressive loss of photoreceptors, and stem cell therapy has become a promising strategy. Many studies have reported that mesenchymal stem cell transplantation can sustain retinal structure and prolong ...
Xiaoxia Li, Jing Xie, Yue Zhai, Tengjiaozi Fang, Nanquan Rao, Shuang Hu, Liping Yang, Yuming Zhao, Yixiang Wang, Lihong Ge   +9 more
doaj   +1 more source

Inhibition of glucocorticoid-induced apoptosis by targeting splice variants of \u3ci\u3eBIM\u3c/i\u3e mRNA with small interfering RNA and short hairpin RNA. [PDF]

, 2004
Glucocorticoids (GCs) induce apoptosis in lymphocytes and are effective agents for the treatment of leukemia. The activated glucocorticoid receptor (GR) initiates a transcriptional program leading to caspase activation and cell death, but the critical ...
Abrams, Marc T., Robertson, Noreen M., Wickstrom, Eric, Yoon, Kyonggeun   +3 more
core   +1 more source

Inhibition of SIRT7 Overcomes Radioresistance in Pancreatic Neuroendocrine Tumors by Reactivating MEN1 Expression

Advanced Science, EarlyView.
Pancreatic neuroendocrine tumors frequently silence MEN1 through epigenetic mechanisms. Here, SIRT7 recruits DNMT1 to the MEN1 promoter, drives hypermethylation, and enhances DNA repair. Inhibiting SIRT7 restores MEN1, reduces MRN complex abundance, impairs double‐strand break repair, and sensitizes PanNET models to radiation, supporting SIRT7 as a ...
Jianyun Jiang, Yan Wang, Yi Qin, Luohai Chen, Xiaowu Xu, Guixiong Fan, Desheng Jing, Miaoyan Wei, Xianjun Yu, Junfeng Xu, Shunrong Ji, Jie Chen   +11 more
wiley   +1 more source

GSHFA-HCP: a novel intelligent high-performance clustering protocol for agricultural IoT in fragrant pear production monitoring

Scientific Reports
The agriculture Internet of Things (IoT) has been widely applied in assisting pear farmers with pest and disease prediction, as well as precise crop management, by providing real-time monitoring and alerting capabilities.
Peng Zhou, Wei Chen, Jing Wang, Huan Wang, Yunfeng Zhang, Bingyu Cao, Shan Sun, Lina He   +7 more
doaj   +1 more source

An energy efficient clustering and routing protocol with data fault prediction using hybrid EAAM with BiLSTM-GRU-IDS in wireless sensor networks

Ain Shams Engineering Journal
Wireless sensor networks (WSNs) and the Internet of Things (IoT) are essential components in various applications. As WSN nodes often function with limited battery life, optimizing energy efficiency becomes crucial for clustering and routing tasks ...
G. Mahalakshmi, S. Ramalingam, A. Manikandan, S. Murugesan   +3 more
doaj   +1 more source

Optimized Longitudinal Monitoring of Stem Cell Grafts in Mouse Brain Using a Novel Bioluminescent/Near Infrared Fluorescent Fusion Reporter

Cell Transplantation, 2017
Biodistribution and fate of transplanted stem cells via longitudinal monitoring has been successfully achieved in the last decade using optical imaging.
Laura Mezzanotte, Juvita Delancy Iljas, Ivo Que, Alan Chan, Eric Kaijzel, Rob Hoeben, Clemens Löwik   +6 more
doaj   +1 more source

CCR5AS lncRNA variation differentially regulates CCR5, influencing HIV disease outcome. [PDF]

, 2019
Multiple genome-wide studies have identified associations between outcome of human immunodeficiency virus (HIV) infection and polymorphisms in and around the gene encoding the HIV co-receptor CCR5, but the functional basis for the strongest of these ...
Anderson, Stephen K, Carrington, Mary, Chowdhury, Fatema Z, Deeks, Steven G, Ewy, Rodger, Gatanaga, Hiroyuki, Goedert, James J, Haas, David W, Hoots, W Keith, Kirk, Gregory D, Kulkarni, Smita, Kulkarni, Viraj, Le Gall, Sylvie, Lied, Alexandra, Lin, Zhansong, Margolick, Joseph, Martin, Maureen P, McLaren, Paul J, Michael, Nelson, Naranbhai, Vivek, Nguyen, Hoang, Oka, Shinichi, Rucevic, Marijana, Singh, Sukhvinder, Takiguchi, Masafumi, Thio, Chloe L, Viard, Mathias, Walker, Bruce, Walker-Sperling, Victoria, Yu, Xu G, Zou, Chengcheng   +30 more
core  

PTP4A1 promotes TGFβ signaling and fibrosis in systemic sclerosis. [PDF]

, 2017
Systemic sclerosis (SSc) is an autoimmune disease characterized by fibrosis of skin and internal organs. Protein tyrosine phosphatases have received little attention in the study of SSc or fibrosis.
Bai, Yunpeng, Boin, Francesco, Bottini, Nunzio, Ceponis, Arnold, Chernitskiy, Vladimir, Cipriani, Paola, Di Benedetto, Paola, Giacomelli, Roberto, Jimenez, Sergio A, Kaestner, Klaus H, Kiosses, William B, Piera-Velazquez, Sonsoles, Sacchetti, Cristiano, Santelli, Eugenio, Stanford, Stephanie M, Zhang, Zhong-Yin   +15 more
core   +2 more sources

Androgen Receptor‐Induced Lactoferrin Accelerates Prostate Tumorigenesis Through Modulating Ferroptosis

Advanced Science, EarlyView.
This study demonstrates that transcription factor androgen receptor (AR) directly binds the LF promoter, driving lactoferrin overexpression to promote ferritin (FTH1/FTL) upregulation and inhibit p53‐ALOX12‐mediated ferroptosis in prostate cancer. Lactoferrin could be a new potential therapeutic target in prostate cancer.
Can Liu, Qiu Peng, Xiaoyue Zhang, Zhengshuo Li, Yangge Wu, Yuqing Wen, Run Zheng, Shuanglong Wu, Chenfei Zhou, Zhengyu Hu, Lanjun Shu, Xinyi Ma, Qiuyang Li, Ya Ma, Chunlin Ou, Ming Zhao, Songqing Fan, Lingyu Wei, Jian Ma   +18 more
wiley   +1 more source

Translesion synthesis DNA polymerase η exhibits a specific RNA extension activity and a transcription-associated function [PDF]

, 2017
We thank Andres Aguilera for providing the pCYC-LacZ plasmid for the GLRO experiments, and Szilvia Minorits for technical assistance. This work was also supported by grants from the National Research, Development and Innovation Office: GINOP-2.3.2-15 ...
Balint, Eva, Frittmann, Orsolya, Gali, Vamsi K, Serbyn, Nataliia, Stutz, Francoise, Unk, Ildiko   +5 more
core   +3 more sources