Results 181 to 190 of about 71,446 (289)

Correction: Emergent periodicity in the collective synchronous flashing of fireflies.

Elife
Sarfati R, Joshi K, Martin O, Hayes JC, Iyer-Biswas S, Peleg O.   +5 more
europepmc   +1 more source

RGX-019-MMAE inhibits leukemia progression by targeting MER proto-oncogene tyrosine kinase (MERTK) in acute myeloid leukemia. [PDF]

J Exp Clin Cancer Res
Tyagi A, Siddiqui M, Eckstrom A, Kurth I, Takeda S, Sharma P, Borthakur G, Yuan B, Abbas HA, Anand V, Borgman J, Kornblau S, Maiti A, Battula VL.   +13 more
europepmc   +1 more source

Oxygen‐independent expression of HIF‐1α during the cell cycle in hepatocellular carcinoma cells controls essential metabolic pathways under normoxia

The FEBS Journal, EarlyView.
In Huh7 cells, HIF‐1α is essential as it maintains the expression of proteins involved in glycolysis and steroid/cholesterol biosynthesis both under normoxia and hypoxia. On the other hand, in HeLa cells, these pathways are induced by HIF‐1α only under hypoxia.
Ioanna‐Maria Gkotinakou, Christina Arseni, Kreon Koukoulas, Martina Samiotaki, George Panayotou, George Simos, Ilias Mylonis   +6 more
wiley   +1 more source

Multimodal tilmanocept for preoperative imaging and fluorescence-guided surgery of porcine lateral pelvic sentinel lymph nodes. [PDF]

Sci Rep
Ogawa R, Kawamura J, Ashworth ET, Park SB, Hall DJ, Kudo M, Hoh CK, Vera DR.   +7 more
europepmc   +1 more source

The ALS‐associated E425K mutation uncouples DNAJC7 from the Hsp70 chaperone cycle

The FEBS Journal, EarlyView.
DNAJC7 is a J‐domain protein that plays a key role in protein quality control by regulating Hsp70 activity and preventing protein aggregation. We find that the ALS‐associated E425K mutation in DNAJC7 disrupts productive interaction and activation of Hsp70, thereby blocking the transfer and refolding of client proteins such as TDP‐43.
Bar Elmaleh, Ofrah Faust, Rina Rosenzweig   +2 more
wiley   +1 more source

Magneto-Photonic Gene Circuit for Minimally Invasive Control of Gene Expression in Mammalian Cells. [PDF]

ACS Omega
Castellanos Franco EA, Radawiec R, Slaviero A, Grady CJ, Ricker B, Pelled G, Hochgeschwender U, Kim T, Gilad AA.   +8 more
europepmc   +1 more source

Quantitative analysis of DNA‐GATA1 binding alterations linked to hematopoietic disorders

The FEBS Journal, EarlyView.
Native holdup allows the quantitative determination of affinities between full‐length transcription factors and DNA. Mutations in either the protein or the DNA can modulate binding strength, which can be precisely quantified using this approach. Applied to GATA1, it revealed mutations that alter DNA binding.
Boglarka Zambo, Bastien Morlet, Luc Negroni, Orsolya Mózner, Balázs Sarkadi, Gilles Travé, Gergo Gogl   +6 more
wiley   +1 more source

Cockayne syndrome mutation in XPG activate the integrated stress response. [PDF]

Hum Genet
Zhang D, Hartmann M, Cao Z, Zhu G, Najjar G, Günes C, Emmert S, Scharffetter-Kochanek K, Iben S.   +8 more
europepmc   +1 more source

RAB4A acts as a negative feedback regulator of extracellular vesicle secretion during TGF‐β signaling

The FEBS Journal, EarlyView.
TGF‐β signaling regulates extracellular vesicle (EV) release in cancer cells by modulating the expression and activity of genes associated with EV biogenesis. The TGF‐β‐induced upregulation of RAB4A expression facilitates fast endosomal recycling, a process that limits the fusion of multivesicular bodies with the plasma membrane and EV secretion. Hence,
Dorival Mendes Rodrigues‐Junior, Maria Anastasia Doumani, Hao Fu, Jelle van den Bor, Olof Idevall‐Hagren, Aristidis Moustakas   +5 more
wiley   +1 more source

Lactate Dehydrogenase Inhibition Reverts the Fatty Acid-Induced Neurotoxic Phenotype of Astrocytes. [PDF]

Glia
Esteve D, Bresque M, Okhuevbie D, Ramachandran S, Pehar M, Vargas MR.   +5 more
europepmc   +1 more source