Results 71 to 80 of about 774,132 (309)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Parish of Megalong [cartographic material] / [PDF]

, 2010
Cadastral map of the Parish of Megalong. Relief shown by hachures.; Publication date based on latest date appearing in series. Sheet 116 "Proclaimed City of Blue Mountains 19th September 1947."; "Blackheath Ward."; Paper print in negative format.; Also ...
H.E.C. Robinson (Firm)
core  

İnovasyon Yapma Olasılığının Belirleyicileri: Ukrayna Firmaları Örneği

Cumhuriyet Üniversitesi İktisadi ve İdari Bilimler Dergisi
Bu çalışma, Rusya ile savaş halinde olan Ukrayna’yı ele alarak firmaların inovasyon (yenilik) yapma olasılıklarını etkileyen faktörleri incelemektedir.
Bayram Veli Doyar
doaj   +1 more source

Considerations Regarding the Notion of “Enterprise” [PDF]

Theoretical and Applied Economics, 2007
The participants of internal and international economic exchanges, the partners that competein a market economy are always the “enterprises”, no matter their name and form.
Cornelia Lefter
doaj  

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Parish of Linden [cartographic material] / [PDF]

, 1947
Cadastral map of the Parish of Linden.; Publication date based on latest date appearing in series. Sheet 116 "Proclaimed City of Blue Mountains 19th September 1947."; In top right corner: "Riding B."; Paper print in negative format.; Also available in an
H.E.C. Robinson (Firm)
core  

Firms plunge into the sea. Marine Biotechnology Industry, a first investigation

Frontiers in Marine Science, 2016
Marine biology made in the last four decades giant leaps. Several scientific and technological breakthroughs shaped research in the marine environment. Thanks to the revelation of the enormous width and complexity of sea life, marine biotechnology began ...
Gaia Raffaella eGreco, Marco eCinquegrani   +1 more
doaj   +1 more source