Results 81 to 90 of about 2,860,655 (313)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

Firms plunge into the sea. Marine Biotechnology Industry, a first investigation

open access: yesFrontiers in Marine Science, 2016
Marine biology made in the last four decades giant leaps. Several scientific and technological breakthroughs shaped research in the marine environment. Thanks to the revelation of the enormous width and complexity of sea life, marine biotechnology began ...
Gaia Raffaella eGreco   +1 more
doaj   +1 more source

Social capital in the workplace: Evidence on its formation and consequences [PDF]

open access: yes, 2008
The existence of social ties between co-workers affect many aspects of firm and worker behavior, such as how workers respond to a given set of incentives, the optimal compensation structures for workers at different tiers of the firm hierarchy, and the ...
Bandiera, O, Barankay, I, Rasul, I
core  

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

Private equity and venture capital financing in the Czech Republic and other european countries – development, opportunities and limitations

open access: yesActa Universitatis Agriculturae et Silviculturae Mendelianae Brunensis, 2011
Financing by means of private equity and venture capital (PE/VC) offers businesses the resources required to finance their future growth and bring prospective business plans and innovative ideas to reality.
Jaroslava Rajchlová   +3 more
doaj   +1 more source

THE EFFECT OF ENTREPRENEURIAL MARKETING ORIENTATION ON COMPETITIVE ADVANTAGE WITH PERCIEVED MARKET TURBULANCE AS A MODERATOR IN THE EXPORT-ORIENTED FOREST PRODUCT INDUSTRY OF SOUTH KALIMANTAN, INDONESIA [PDF]

open access: yesRussian Journal of Agricultural and Socio-Economic Sciences, 2022
Bundling resources from Market Orientation (MO), Entrepreneurial Orientation (EO) and Innovation Orientation (IO), and Customer Relationship Orientation (CRO) which are dimensions of Entrepreneurial Marketing Orientation (EMO) can be a source of ...
Helmi M., Naparin M.
doaj  

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

Firm attributes and share price fluctuation of deposit money banks listed in Nigeria

open access: yesJurnal Ekonomi Modernisasi, 2019
This paper examined firms’ attributes impact on the fluctuation of share prices of listed deposit money banks in Nigeria. Ex-post facto research design was employed, and 13 deposit money banks firms were selected out of 15 from 2006-2016.
Adamu Adamu Idris   +2 more
doaj   +1 more source

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