Results 121 to 130 of about 1,434,413 (310)

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Investigating the effect of environmental performance and corporate characteristics on the achievement of SDGs and enhancement of firm value

Economics and Environment
This study rigorously explains the contribution of environmental performance, firm characteristics, sustainable development goals, and firm value in mining firms listed on the Indonesia Stock Exchange from 2019 to 2022.
Edwin Agus Buniarto, Nur Sayidah, Dian Ferriswara, Fedianty Augustinah, Amirul Mustofa   +4 more
doaj   +1 more source

Boardroom Centrality and Firm Performance

Nordic Journal of Business, 2022
We study the link between boardroom centrality and operating performance in private firms. We argue that the centrality-performance relationship is stronger for private firms whose increased connectedness is likely to provide certification benefits, decrease transaction costs by reducing information asymmetry, and improve access to critical resources ...
Afzali, Mansoor, Kettunen, Jukka
openaire   +2 more sources

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

ARE POLITICAL CONNECTIONS IMPORTANT FOR FIRM PERFORMANCE? [PDF]

, 2017
Department of Management EngineeringWe explore the influence of political connections on the firm performance. An analysis of data from 395 Korean listed firms in manufacturing sector during 2011-2015 reveals that firms with high levels of political ...
Cho, DooYoung
core  

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Firm Culture and Leadership as Firm Performance Predictors: a Resource-Based Perspective [PDF]

In this study, we tested part of the resource-based view of the firm by examining two 'soft' resources, firm culture and top leadership, as predictors of 'hard' or bottom-line firm performance.Transformational top leadership was found to predict firm ...
Berg, P. van den, Wilderom, C.P.M.
core   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

EMA on Firm Value: A Moderating Role Of Firm Performance

Jurnal Akuntansi: Kajian Ilmiah Akuntansi
This study aims to examine the effect of EMA on firm value: a moderated role of firm performance. The population in this study are palm oil companies listed on the Indonesia Stock Exchange.
Ika Rahmadani, Linda Rahmazaniati, Sari Maulida Vonna, Rina Maulina, Tamitha Intassar Husen, Winda Putri Diah Restya, Septiana Dian Hatami Harahap   +6 more
doaj   +1 more source