Results 61 to 70 of about 1,470,980 (360)
Molecular Oncology, EarlyView.This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert +13 more
wiley +1 more source
ESG and firm performance: The role of digitalization [PDF]
, 2023 Rizky Eriandani, Wahyu Agus Winarno
openalex +1 more source
Technological Innovation Performance Analysis Using Multilayer Networks: Evidence from the Printer Industry [PDF]
, 2020 Department of Management EngineeringThe importance of collaboration and technology boundary spanning has been emphasized in other inquiries into technological innovation.
Lee, Jung-Min
core
Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine
Molecular Oncology, EarlyView.The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu +18 more
wiley +1 more source
State Ownership and Firm Performance: Evidence From the Chinese Listed Firms
Organizations and Markets in Emerging Economies, 2011 Based on a sample of Chinese listed firms, this paper seeks to understand the role of state ownership on firm performance (accounting-based returns) and firm value (market-based indicators). Results show that state ownership is positively associated with
Trien Le, Amon Chizema
doaj +1 more source
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Innovation and firm performance [PDF]
Understanding the relation between innovation and performance in both large, medium, and small firms is of crucial importance for ongoing economic growth, but still hardly understood.
Jeroen de Jong +3 more
core +3 more sources
Regulation and firm perception, eco‐innovation and firm performance [PDF]
European Journal of Innovation Management, 2012 PurposeRecent reports argue that eco‐innovation is the key to realising growth. The purpose of this paper is to examine the factors which drive eco‐innovation and test if eco‐innovating firms perform better than non‐eco‐innovating firms. The paper provides insights into the role government regulation can play in directing and stimulating eco‐innovation.
Doran, Justin, Ryan, Geraldine
openaire +3 more sources
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
Political environment, employee tenure security and firm performance in middle-income economies [PDF]
, 2023 Nicholas Addai Boamah +2 more
openalex +1 more source