Results 71 to 80 of about 129,552 (313)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Partial Privatization and Firm Performance [PDF]

open access: yesSSRN Electronic Journal, 2003
ABSTRACTMost privatization programs begin with a period of partial privatization in which only non‐controlling shares of firms are sold on the stock market. Since management control is not transferred to private owners it is widely contended that partial privatization has little impact.
openaire   +2 more sources

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

Dimensions of human capital and firm performance: Micro-firm context

open access: yesIIMB Management Review, 2018
The objective of the paper is twofold: first, to examine the dimensions of human capital with respect to a measurement model; second, to test the direct and mediating relationships between human capital dimensions and firm performance.
Eijaz Ahmed Khan, Mohammed Quaddus
doaj   +1 more source

Sustainability reporting and firm performance

open access: yesPressacademia, 2019
Purpose- The aim of this paper is to examine sustainability reporting and its relation with firm performance.  We investigate whether such reporting practices improve the firm value while enhancing its profitability and the financial leverage impact on sustainability reporting in the automotive industry.
KAYA, İdil, HALİT AKBULUT, Destan
openaire   +3 more sources

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

The Effect of Board Characteristics on Firm Performance in Japan

open access: yesEast Asian Economic Review, 2009
This paper analyzes the effect of similarity among board members on firm performance in Japanese manufacturing firms. The similarity measures regarding age and educational background of individual directors were used to predict firm performance.
Oona Cha , Taehun Jung
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

Impact of human resource slacks on firm performance: Evidence from a developing country [PDF]

open access: yesZbornik radova Ekonomskog fakulteta u Rijeci : časopis za ekonomsku teoriju i praksu, 2013
Purpose of this paper is to investigate whether HR slack leads to improve firm performance, and what is the impact of HR slack in absolute and in relative terms on firm performance in a developing country.
M.M. Fonseka   +2 more
doaj  

Efficacy of firm size and structure on organizational performance [PDF]

open access: yesЕкономіка та управління АПК
Firm size plays an important role in determining firm’s performance even though it’s not clear whether firm size affect organizational perfor[1]mance. Therefore; an investigation is required to assess the effect firm size and structure will have on firm ...
OLALEKAN OWOTUTU SABITU   +2 more
doaj   +1 more source

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