Results 71 to 80 of about 80,092 (269)
FEBS Open Bio, EarlyView.This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel +4 more
wiley +1 more source
The growth opportunities for SMC?
Journal of Business Economics and Management, 2006 The extensive empirical literature on the validity of Gibrat's law does not in general verify the law as it finds that firms’ growth rates are negatively correlated with both firm size and age.
Jan Bentzen +2 more
doaj +1 more source
Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis
FEBS Open Bio, EarlyView.Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho +4 more
wiley +1 more source
YIPFα1A expression is regulated by multilayered molecular mechanisms
FEBS Open Bio, EarlyView.YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji +2 more
wiley +1 more source
USING THE SOFTWARE MICROSOFT OFFICE EXCEL FOR FINANCIAL MODELING DECISION [PDF]
Analele Universităţii Constantin Brâncuşi din Târgu Jiu : Seria Economie, 2009 The use of the software package is today indispensable for modeling of financial decisions. Business organizations will invariably make greater demands of the software than individual users.
Bălăc escu Aniela
doaj
Firms as a Component of Smart Specialisation in the Opolskie Voivodship Development Strategy
Barometr Regionalny, 2015 The main goal of the paper is to study the significance of businesses as a component of smart specialization, on the basis of the Opolskie Voivodship Development Strategy. The structure of the paper consists of two sections. The first part is related to
Justyna Zygmunt
doaj +1 more source
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
Innovation activities of firms: the case of 8 cis waves in the Czech industry between 2001 and 2014
SHS Web of Conferences, 2017 Eight Czech CIS waves between 2001-2014 were analyzed. An adjusted (incomplete) CDM model was used to estimate effects of characteristics of firms (firm size, government funding, market orientation, or foreign ownership) on the innovation process ...
Vokoun Marek
doaj +1 more source
FEBS Open Bio, EarlyView.Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin +3 more
wiley +1 more source
The improving of methodological principles of enterprise competitiveness management under the crisis
Agricultural and Resource Economics, 2016 The purpose of this research is methodological bases improving and forming of practical tools for enterprise competitiveness management under the crisis. The specific features of the competitive environment of enterprises in Ukraine under the global and
Marina Dyadyuk
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