Results 51 to 60 of about 29,704,411 (288)

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Reliability analysis of mooring chains for floating offshore wind turbines

Frontiers in Built Environment
As offshore wind farms move into deeper waters, around 80 m, the high costs necessitate replacing bottom-fixed turbines with floating offshore wind turbines, which require mooring systems to maintain stability within design limits.
Guangming Li, Tianguo Pan, Ruming Feng, Liyun Zhu   +3 more
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Reliability methods in dynamic system analysis [PDF]

, 2013
textStandard techniques used to analyze a system's response with uncertain system parameters or inputs, are generally Importance sampling methods. Sampling methods require a large number of simulation runs before the system output statistics can be ...
Munoz, Brad Ernest
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Contact stress reliability analysis based on first order second moment for variable hyperbolic circular arc gear

Advances in Mechanical Engineering, 2022
Aiming at the contact strength reliability of variable hyperbolic circular arc gear, a reliability analysis method for contact strength of variable hyperbolic circular arc gear based on Kriging model and advanced first-order and second-moment algorithm ...
Zhang Qi, Wen Guang, Chen Zhixin, Zhou Qin, Xiang Guoqi, Yang Guangchun, Zhang Xuegang   +6 more
doaj   +1 more source

THE THEORY OF COMPLEX PROBABILITY AND THE FIRST ORDER RELIABILITY METHOD [PDF]

Journal of Mathematics and Statistics, 2013
The Kolmogorov’s system of axioms can be extended to encompass the imaginary set of numbers and this by adding to the original five axioms an additional three axioms. Hence, any experiment can thus be executed in what is now the complex set C (Real set R with real probability + Imaginary set M with imaginary probability).
openaire   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers

FEBS Letters, EarlyView.
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui, Agnes Banreti, Armelle L. Ernst, Guillaume Leseigneur, Uwe J. Meierhenrich   +4 more
wiley   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Illustrated structural application of universal first-order reliability method [PDF]

, 1994
The general application of the proposed first-order reliability method was achieved through the universal normalization of engineering probability distribution data.
Verderaime, V.
core