Results 111 to 120 of about 6,363,291 (243)
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Creating First-Mover Advantages: The Case of Samsung Electronics [PDF]
This paper analyzes the sources of first-mover advantages by examining the case of Samsung Electronics, a firm which has maintained and strengthened the technological leadership in the DRAM industry since 1992.
Jang-Sup SHIN, Sung-Won JANG
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Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
, 2019 Table of Contents: An Update from the Deans: Q & A Case Western Reserve University School of Law raises $58 million, capped off by a $10 million landmark gift from an alumnus to establish the Coleman P.
Case Western Reserve University School of Law
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The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Protecting Everyone\u27s Constitutional Rights: Panel on Qualified Immunity
, 2023 Qualified immunity is a doctrine invented by the Supreme Court in 1982 which protects all government officials from liability when they violate a person’s rights, even intentionally.
Case Western Reserve University School of Law
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Electron transfer between complexes III and IV in S. cerevisiae mitochondrial membranes
FEBS Letters, EarlyView.Mitochondrial oxidative phosphorylation in S. cerevisiae mitoplasts is limited by complex IV catalytic capacity, rather than two‐dimensional cytochrome c diffusion. At physiological cytochrome c : supercomplex ratios at salinity equivalent to that of 20 mm monovalent salt, activity is maximized, indicating that this low ionic strength accurately mimics
Ana Paula Lobez +2 more
wiley +1 more source
Alexander H. Martin, Class of 1895 Mr. Martin graduated Phi Beta Kappa from Adelbert College in 1895. He was one of six African American members of the Phi Beta Kappa honorary society in the 19th century. After graduation, Mr.
Johnson, Gwendolyn G. (Creatorcre) +1 more
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, 2011 Case Downtown First Amendment (9/14/2011) Assoc. Dean Jonathan Entin, Case Western Reserve University School of Law Dean Johnathan Entin discusses landmarks First Amendment Cases.
Entin, Jonathan L.
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