Study protocol for a randomised, controlled platform trial estimating the effect of autobiographical Memory Flexibility training (MemFlex) on relapse of recurrent major depressive disorder. [PDF]
, 2018 INTRODUCTION: Major depressive disorder (MDD) is a chronic condition. Although current treatment approaches are effective in reducing acute depressive symptoms, rates of relapse are high. Chronic and inflexible retrieval of autobiographical memories, and
Aliza Werner-Seidler +10 more
core +3 more sources
484 – Depression and Suicidality in First Episode Psychosis
European Psychiatry, 2013 A clearer understanding of the ebb and flow of depression and suicidal thinking in the early phase of psychosis, and how this relates to other symptom dimensions, is essential for developing interventions to reduce risk. The studies presented here investigate whether depression and suicidal thinking are predictable, how they relate to the early course ...
R. Upthegrove +5 more
openaire +1 more source
Arthritis Care &Research, Accepted Article.Objective Somatic items used in depression assessments can potentially overlap with symptoms related to physical illness, including systemic sclerosis (SSc). No studies have looked at whether somatic depression items may be influenced by diffuse versus limited SSc disease subtypes, which are associated with varying degrees of symptom presentation.
Sophie Hu +109 more
wiley +1 more source
The Sleep Or Mood Novel Adjunctive therapy (SOMNA) trial: a study protocol for a randomised controlled trial evaluating an internet-delivered cognitive behavioural therapy program for insomnia on outcomes of standard treatment for depression in men [PDF]
, 2015 BACKGROUND: Insomnia is a significant risk factor for depression onset, can result in more disabling depressive illness, and is a common residual symptom following treatment cessation that can increase the risk of relapse.
Christensen, Helen M. +7 more
core +2 more sources
Multi‐Site Transfer Classification of Major Depressive Disorder: An fMRI Study in 3335 Subjects
Advanced Science, EarlyView.The study proposes graph convolution network with sparse pooling to learn the hierarchical features of brain graph for MDD classification. Experiment is done on multi‐site fMRI samples (3335 subjects, the largest functional dataset of MDD to date) and transfer learning is applied, achieving an average accuracy of 70.14%.
Jianpo Su +14 more
wiley +1 more source
Frontiers in Psychiatry, 2020 Several studies have reported a link between lipid disorders and suicidality. However, few studies have investigated the relationship between suicidal behavior and blood lipid profiles in patients with first-episode and drug-naive (FEDN) major depressive
Yue-Jiao Ma +10 more
doaj +1 more source
Ecologically‐Valid Emotion Signatures Enhance Mood Disorder Diagnostics
Advanced Science, EarlyView.This study identifies ecologically‐valid Divergent Emotional Functional Networks (DEFN), derived from dynamic functional connectivity during naturalistic movie watching. The DEFN reliably enhances diagnostic accuracy for mood disorders, including major depressive and bipolar disorders, demonstrating strong reproducibility across demographic factors and
Shuyue Xu +6 more
wiley +1 more source
Suicidal risk and executive functions in major depressive disorder: a study protocol
BMC Psychiatry, 2019 Background Suicide is a serious public health concern. Depression is the main gateway to suicidal behavior. The already established relationship between depression and suicidal risk should now focus on the investigation of more specific factors: recent ...
Miquel Roca +8 more
doaj +1 more source
The impact of high frequency repetitive transcranial magnetic stimulation on fine motor function in medication resistant major depression [PDF]
, 2012 <b><i>Objectives:</i></b> Although high-frequency repetitive transcranial magnetic stimulation (HF-rTMS) over the left dorsolateral prefrontal cortex (DLPFC) has been reported to improve mood symptoms in major depressive disorder (
Baeken, Chris +3 more
core +1 more source
Midbrain PAG Astrocytes Modulate Mouse Defensive and Panic‐Like Behaviors
Advanced Science, EarlyView.Astrocytes in the midbrain periaqueductal gray (PAG) dynamically encode threat intensity and shape defensive action selection in mice. Real‐time Ca2+ imaging reveals robust astrocytic activation during predator odor and CO2 exposure. Aberrant astrocytic Ca2+ overactivation disrupts goal‐directed escape, biases behavior toward freezing, and induces ...
Ellane Barcelon +10 more
wiley +1 more source